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Scientific Reports (6)
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Showing 1–9 of 9 results

Advanced filters: Author: Ryuichi Ohgaki Clear advanced filters

Structural basis of anticancer drug recognition and amino acid transport by LAT1

Lee et al. report six cryo-EM structures of LAT1 in complex with various substrates and inhibitors, including nanvuranlat (JPH203) under clinical trials. These structures provide insights into the mechanisms of amino acid transport and inhibition, aiding future drug design.

Yongchan Lee
Chunhuan Jin
Yoshikatsu Kanai
ResearchOpen Access14 Feb 2025
Nature Communications

Volume: 16, P: 1-12
Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2

EAAT2 is an amino acid transporter implicated in glutamate homeostasis in brain and therapy resistance of cancer cells. Here, the authors report cryo-EM structures and reveal inhibitory mechanisms via selective inhibitor WAY213613.

Takafumi Kato
Tsukasa Kusakizako
Osamu Nureki
ResearchOpen Access11 Aug 2022
Nature Communications

Volume: 13, P: 1-11
Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc

Cryo-EM structure of the LAT1–CD98hc heterodimer in complex with two antibodies offers insights into the assembly and function of LAT1–CD98hc, and reveals the epitopes targeted by the potentially therapeutic antibodies with an antitumor activity.

Yongchan Lee
Pattama Wiriyasermkul
Osamu Nureki
Research03 Jun 2019
Nature Structural & Molecular Biology

Volume: 26, P: 510-517
Amino acid transporter LAT1 is expressed on cancer cell-derived exosomes with potential as a diagnostic and prognostic biomarker

Yumiao Liu
Ryuichi Ohgaki
Yoshikatsu Kanai
ResearchOpen Access18 Nov 2024
Scientific Reports

Volume: 14, P: 1-10
LAT1 expression in colorectal cancer cells is unresponsive to HIF-1/2α accumulation under experimental hypoxia

Ryuichi Ohgaki
Yuma Hirase
Yoshikatsu Kanai
ResearchOpen Access23 Aug 2024
Scientific Reports

Volume: 14, P: 1-12
Pharmacological and structural insights into nanvuranlat, a selective LAT1 (SLC7A5) inhibitor, and its N-acetyl metabolite with implications for cancer therapy

Chunhuan Jin
Xinyu Zhou
Yoshikatsu Kanai
ResearchOpen Access23 Jan 2025
Scientific Reports

Volume: 15, P: 1-14
Structure–activity characteristics of phenylalanine analogs selectively transported by L-type amino acid transporter 1 (LAT1)

Sihui Chen
Chunhuan Jin
Yoshikatsu Kanai
ResearchOpen Access26 Feb 2024
Scientific Reports

Volume: 14, P: 1-13
Inhibition of cancer-type amino acid transporter LAT1 suppresses B16-F10 melanoma metastasis in mouse models

Zitong Shi
Kazuko Kaneda-Nakashima
Yoshikatsu Kanai
ResearchOpen Access25 Aug 2023
Scientific Reports

Volume: 13, P: 1-16
Ratiometric fluorescence imaging of cell surface pH by poly(ethylene glycol)-phospholipid conjugated with fluorescein isothiocyanate

Ryuichi Ohgaki
Yuji Teramura
Yoshikatsu Kanai
ResearchOpen Access13 Dec 2017
Scientific Reports

Volume: 7, P: 1-9