The adhesive interaction of cells with the environment through integrins regulates multiple aspects of cellular physiology. The prominence of gene mutations in specific constituents of integrin-mediated adhesions, which are collectively known as the 'integrin adhesome', in diverse pathological states, is providing insight into the molecular mechanisms that underlie these diseases.
- Sabina E. Winograd-Katz
- Reinhard Fässler
- Kyle R. Legate
