Nature Search

Cytoplasmic versus nuclear localization of androgen receptor splice variant 7 as a predictor of benefit from androgen receptor pathway inhibitors in metastatic castration-resistant prostate cancer (PROPHECY trial)

Santosh Gupta
Siyuan Guo
Andrew J. Armstrong
Research02 Apr 2026
Prostate Cancer and Prostatic Diseases

P: 1-9
AR alterations inform circulating tumor DNA detection in metastatic castration resistant prostate cancer patients

Liquid biopsy assays are important to prognosticate outcomes of metastatic castration-resistant prostate cancer (mCRPC) patients treated with androgen receptor (AR) inhibitors. Here this group reports detecting circulating tumor DNA in limiting plasma cell-free DNA of mCRPC patients as prognostic marker of poor survival after AR treatment.

Todd P. Knutson
Bin Luo
Scott M. Dehm
ResearchOpen Access11 Dec 2024
Nature Communications

Volume: 15, P: 1-15
Early favorable prostate-specific antigen response prediction in metastatic hormone sensitive prostate cancer

There is a need for an easy-to-use clinical tool, that could predict favorable early PSA response and subsequently enhance early risk stratification, as well as guide treatment planning. Here, the authors show that based on patient data from four phase III randomized trials, Nadir androgen receptor pathway inhibitor (APRI)- Derived Integrative Response (NADIR) model predicts favorable early PSA response to ≤0.2 ng/mL by 6 months in metastatic hormone sensitive prostate cancer (mHSPC) patients initiating treatment with an APRI.

Soumyajit Roy
Yilun Sun
Daniel E. Spratt
ResearchOpen Access17 Dec 2025
Nature Communications

Volume: 17, P: 1-10
Population-specific calibration and validation of an open-source bone age AI

Sebastian Rassmann
Luka Abashishvili
Behnam Javanmardi
ResearchOpen Access23 Sept 2025
Scientific Reports

Volume: 15, P: 1-8
Targeting immunosuppressive myeloid cells via implant-mediated slow release of small molecules to prevent glioblastoma recurrence

A biodegradable implant inserted after tumour removal sustainably releases immune modulators and reprograms tumour-infiltrating myeloid cells toward a pro-inflammatory, antitumour phenotype, offering a promising therapeutic strategy for preventing glioblastoma recurrence.

Yannik Kaiser
Christopher S. Garris
Ralph Weissleder
ResearchOpen Access22 Oct 2025
Nature Biomedical Engineering

P: 1-14
A systematic exploration of digital biomarkers for the detection of depressive episodes in bipolar disorder

Ramzi Halabi
Benoit H. Mulsant
Abigail Ortiz
ResearchOpen Access22 Feb 2026
npj Mental Health Research

Volume: 5, P: 1-13
Phase 2 study of circulating microRNA biomarkers in castration-resistant prostate cancer

Hui-Ming Lin
Kate L Mahon
Lisa G Horvath
ResearchOpen Access09 Mar 2017
British Journal of Cancer

Volume: 116, P: 1002-1011
Novel coenzyme Q6 genetic variant increases susceptibility to pneumococcal disease

Morley, Pomat and colleagues identify a homozygous mutation in COQ6 in an indigenous population of Papua New Guinea. This allele predisposes children to increased risk of acute lower respiratory infections in response to Streptococcus pneumoniae. This sensitivity is recapitulated in Coq6DY mice in the nonhematopoietic compartment.

Emma C. Walker
Sarah Javati
Sharon Celeste Morley
Research04 Nov 2024
Nature Immunology

Volume: 25, P: 2247-2258
Author Correction: SVEP1 is an endogenous ligand for the orphan receptor PEAR1

Jared S. Elenbaas
Upasana Pudupakkam
Nathan O. Stitziel
Amendments and CorrectionsOpen Access17 Mar 2023
Nature Communications

Volume: 14, P: 1
SVEP1 is an endogenous ligand for the orphan receptor PEAR1

SVEP1 is linked to numerous human diseases, though its disease-promoting mechanism has remained unclear. Here, the authors identify SVEP1 as a ligand for the orphan receptor PEAR1 and provide insight into the role of this interaction in cardiovascular disease.

Jared S. Elenbaas
Upasana Pudupakkam
Nathan O. Stitziel
ResearchOpen Access15 Feb 2023
Nature Communications

Volume: 14, P: 1-18
Prognostic value of serum alkaline phosphatase in spinal metastatic disease

Aditya V. Karhade
Quirina C. B. S. Thio
Joseph H. Schwab
ResearchOpen Access22 Feb 2019
British Journal of Cancer

Volume: 120, P: 640-646
Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis

Multi-ancestry genome-wide association analyses identify 124 risk loci for rheumatoid arthritis, of which 34 are novel. A polygenic risk score based on multi-ancestry data showed comparable performance between populations of European and East Asian ancestries.

Kazuyoshi Ishigaki
Saori Sakaue
Soumya Raychaudhuri
Research04 Nov 2022
Nature Genetics

Volume: 54, P: 1640-1651
PSA as an intermediate end point in clinical trials

The 2009 study by Hussain et al. showed that a PSA-based intermediate end point might be useful in clinical trials of advanced prostate cancer. However, overall survival (OS) will remain the required end point of phase III studies and the search for a true, robust surrogate of OS to accelerate drug development continues.

Gerhardt Attard
Johann S. de Bono
News & Views01 Sept 2009
Nature Reviews Urology

Volume: 6, P: 473-475
Single-dose pharmacokinetics, safety, and tolerability of the dual endothelin receptor antagonist aprocitentan in subjects with moderate hepatic impairment

Magda S. C. Fontes
Jasper Dingemanse
Patricia N. Sidharta
ResearchOpen Access09 Nov 2022
Scientific Reports

Volume: 12, P: 1-7
Decoupled hydrogen and oxygen evolution by a two-step electrochemical–chemical cycle for efficient overall water splitting

Conventionally, the two half reactions involved in water electrolysis occur simultaneously, presenting materials and process challenges. Here, the authors decouple these to split water efficiently in two steps: electrochemical hydrogen evolution, followed by spontaneous oxygen evolution at elevated temperature.

Hen Dotan
Avigail Landman
Gideon S. Grader
Research13 Sept 2019
Nature Energy

Volume: 4, P: 786-795
Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis

Thymic epithelial tumors are associated with increased risk of immune checkpoint inhibitor (ICI)-induced myotoxicities, and the presence of anti-acetylcholine-receptor antibodies has the potential to serve as a biomarker for ICI-induced myocarditis in patients with cancer.

Charlotte Fenioux
Baptiste Abbar
Joe-Elie Salem
Research26 Oct 2023
Nature Medicine

Volume: 29, P: 3100-3110
Artificial intelligence for the detection of COVID-19 pneumonia on chest CT using multinational datasets

Chest CT is emerging as a valuable diagnostic tool for clinical management of COVID-19 associated lung disease. Here, the authors present a multinational study on the application of deep learning algorithms for COVID-19 diagnosis against multiple lung conditions as controls.

Stephanie A. Harmon
Thomas H. Sanford
Baris Turkbey
ResearchOpen Access14 Aug 2020
Nature Communications

Volume: 11, P: 1-7
Clinical implications of Wnt pathway genetic alterations in men with advanced prostate cancer

Amanda Broderick
Elizabeth Pan
Andrew J. Armstrong
Research17 Jul 2024
Prostate Cancer and Prostatic Diseases

Volume: 28, P: 419-426
Pediatric myxopapillary ependymoma treated with subtotal resection and radiation therapy: a case report and review of the literature

H Shirasawa
K Ishii
M Nakamura
Research01 Aug 2014
Spinal Cord

Volume: 52, P: S18-S20
Circulating microRNAs are associated with docetaxel chemotherapy outcome in castration-resistant prostate cancer

H-M Lin
L Castillo
L G Horvath
ResearchOpen Access08 Apr 2014
British Journal of Cancer

Volume: 110, P: 2462-2471
The relationship of body mass index and serum testosterone with disease outcomes in men with castration-resistant metastatic prostate cancer

A J Armstrong
S Halabi
M Eisenberger
Research24 Jun 2008
Prostate Cancer and Prostatic Diseases

Volume: 12, P: 88-93
Association between overweight and obesity determined by body mass index and overall survival in patients with metastatic prostate cancer: a meta-analysis

Feilun Cui
Yueshi Zhang
Yu Fan
Reviews15 Aug 2025
International Journal of Obesity

Volume: 49, P: 2131-2139
Survival of African-American and Caucasian men after sipuleucel-T immunotherapy: outcomes from the PROCEED registry

Oliver Sartor
Andrew J. Armstrong
Celestia S. Higano
ResearchOpen Access28 Feb 2020
Prostate Cancer and Prostatic Diseases

Volume: 23, P: 517-526
Psychological predictors of attendance at annual breast screening examinations

MV Burton
R Warren
H Earl
Research01 Jun 1998
British Journal of Cancer

Volume: 77, P: 2014-2019
Optimal timing and dosage of chemotherapy as a combined treatment with androgen withdrawal in the human prostate LNCaP tumour model

H Miyake
S Hara
I Hara
ResearchOpen Access20 Mar 2001
British Journal of Cancer

Volume: 84, P: 859-863
Body mass index and mortality in prostate cancer patients: a dose–response meta-analysis

S Zhong
X Yan
J Zhao
Reviews12 Jan 2016
Prostate Cancer and Prostatic Diseases

Volume: 19, P: 122-131
Author Correction: Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis

Charlotte Fenioux
Baptiste Abbar
Joe-Elie Salem
Amendments and Corrections27 Nov 2023
Nature Medicine

Volume: 29, P: 3268
The presenting dental status of solid tumours with bone metastases requiring bone-targeting agents - part 3: prostate cancer

Vinod Patel
Megan Burns
Marianne Henien
Research10 Feb 2022
British Dental Journal

P: 1-5
Publisher Correction: Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis

Charlotte Fenioux
Baptiste Abbar
Joe-Elie Salem
Amendments and Corrections03 Jan 2024
Nature Medicine

Volume: 30, P: 910
Labor induction with oxytocin in pregnant rats is not associated with oxidative stress in the fetal brain

Tusar Giri
Jia Jiang
Arvind Palanisamy
ResearchOpen Access24 Feb 2022
Scientific Reports

Volume: 12, P: 1-12
Exploratory analysis of the visceral disease subgroup in a phase III study of abiraterone acetate in metastatic castration-resistant prostate cancer

O B Goodman Jr
T W Flaig
H I Scher
ResearchOpen Access01 Oct 2013
Prostate Cancer and Prostatic Diseases

Volume: 17, P: 34-39
Dietary composition and overlap between cattle and endangered mountain gazelle (Gazella gazella)

Amir Arnon
Torsten Wronski
Dan Malkinson
ResearchOpen Access06 Jun 2025
Scientific Reports

Volume: 15, P: 1-12
Genetic determinants of severe COVID-19 in young Asian and Middle Eastern patients: a case series

Beshr Abdulaziz Badla
Mohamed Samer Hanifa
Ahmad Abou Tayoun
ResearchOpen Access20 Nov 2023
Scientific Reports

Volume: 13, P: 1-11
Zika virus infection damages the testes in mice

Infection of male mice with Zika virus caused testicular and epididymal damage, reduction in sex hormone levels, destruction of germ and somatic cells in the testis, loss of mature sperm and reduction in fertility.

Jennifer Govero
Prabagaran Esakky
Michael S. Diamond
Research31 Oct 2016
Nature

Volume: 540, P: 438-442
Attention-guided deep learning for gestational age prediction using fetal brain MRI

Liyue Shen
Jimmy Zheng
Kristen W. Yeom
ResearchOpen Access26 Jan 2022
Scientific Reports

Volume: 12, P: 1-10
Evaluation of an epithelial plasticity biomarker panel in men with localized prostate cancer

A J Armstrong
P Healy
S J Freedland
Research13 Oct 2015
Prostate Cancer and Prostatic Diseases

Volume: 19, P: 40-45
Cytokine profiling of docetaxel-resistant castration-resistant prostate cancer

K L Mahon
H-M Lin
L G Horvath
ResearchOpen Access31 Mar 2015
British Journal of Cancer

Volume: 112, P: 1340-1348
Publisher Correction: Labor induction with oxytocin in pregnant rats is not associated with oxidative stress in the fetal brain

Tusar Giri
Jia Jiang
Arvind Palanisamy
Amendments and CorrectionsOpen Access14 Mar 2022
Scientific Reports

Volume: 12, P: 1
Short-course antibiotic therapy for pneumonia in the neonatal intensive care unit

Zachery S. Lewald
Pavel Prusakov
Roopali Bapat
Research12 Jul 2023
Journal of Perinatology

Volume: 43, P: 1145-1151
Androgen receptor variant-driven prostate cancer II: advances in clinical investigation

Landon C. Brown
Changxue Lu
Andrew J. Armstrong
Reviews24 Feb 2020
Prostate Cancer and Prostatic Diseases

Volume: 23, P: 367-380
A phase 2 multimodality trial of docetaxel/prednisone with sunitinib followed by salvage radiation therapy in men with PSA recurrent prostate cancer after radical prostatectomy

A J Armstrong
S Halabi
D J George
Research12 Jan 2016
Prostate Cancer and Prostatic Diseases

Volume: 19, P: 100-106
PROMISE: a real-world clinical-genomic database to address knowledge gaps in prostate cancer

Vadim S. Koshkin
Vaibhav G. Patel
Rana McKay
ReviewsOpen Access06 Aug 2021
Prostate Cancer and Prostatic Diseases

Volume: 25, P: 388-396
A phase 2 autologous cellular therapy trial in patients with acute, complete spinal cord injury: pragmatics, recruitment, and demographics

L A T Jones
D P Lammertse
D A Snyder
Research13 Apr 2010
Spinal Cord

Volume: 48, P: 798-807

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