Nature Search

Airway hillocks are injury-resistant reservoirs of unique plastic stem cells

In the lungs, recently identified epithelial structures known as hillocks can act as injury-resistant reservoirs of stem cells.

Brian Lin
Viral S. Shah
Jayaraj Rajagopal
Research01 May 2024
Nature

Volume: 629, P: 869-877
Energy deposition by heavy ions: Additivity of kinetic and potential energy contributions in hillock formation on CaF₂

Y. Y. Wang
C. Grygiel
M. Toulemonde
ResearchOpen Access18 Jul 2014
Scientific Reports

Volume: 4, P: 1-6
Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer

Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining neuroendocrine–tuft heterogeneity and offering new perspectives for targeting lineage plasticity.

Abbie S. Ireland
Daniel A. Xie
Trudy G. Oliver
ResearchOpen Access17 Sept 2025
Nature

Volume: 647, P: 257-267
Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses

The immune suppressive tumour microenvironment drives recurrence and metastatic disease in prostate cancer. Here authors provide a detailed analysis of the microenvironment via single cell RNA sequencing and high-resolution spatial transcriptomics to identify tumour-dependent changes compared to healthy tissue.

Taghreed Hirz
Shenglin Mei
David B. Sykes
ResearchOpen Access07 Feb 2023
Nature Communications

Volume: 14, P: 1-20
Single-cell division tracing and transcriptomics reveal cell types and differentiation paths in the regenerating lung

This study uses single-cell transcriptomics to examine how lung cells respond to targeted damage. The authors employ genetically modified mouse models and cell sorting to enrich for rare, actively dividing cells, revealing cell types/states and alternative differentiation paths.

Leila R. Martins
Lina Sieverling
Claudia Scholl
ResearchOpen Access12 Mar 2024
Nature Communications

Volume: 15, P: 1-20
Single cell analysis of cribriform prostate cancer reveals cell intrinsic and tumor microenvironmental pathways of aggressive disease

The molecular and cellular underpinnings of cribriform prostate cancer aggressiveness remain to be explored. Here, the authors perform single-cell RNA-sequencing, TCR sequencing and histology and reveal cancer cell intrinsic pathways and an immunosuppressive tumour microenvironment.

Hong Yuen Wong
Quanhu Sheng
Paula J. Hurley
ResearchOpen Access13 Oct 2022
Nature Communications

Volume: 13, P: 1-21
ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L

Lineage tracing in mice identifies a subpopulation of basal cells that express Tmprss2 and Nkx3 as the origin of ERG-driven prostate cancer. Upon expansion, these cells show an enrichment for STAT3 chromatin binding and elevated expression of KMT2A and DOT1L as dependencies for ERG oncogenicity.

Weiran Feng
Erik Ladewig
Charles L. Sawyers
ResearchOpen Access26 Aug 2025
Nature Genetics

Volume: 57, P: 2177-2191
Single cell and spatial transcriptomics highlight the interaction of club-like cells with immunosuppressive myeloid cells in prostate cancer

The prostate cancer tumour microenvironment in the context of treatment remains to be explored. Here, single-cell RNA-sequencing and spatial transcriptomics analysis of samples at multiple treatment points from 120 patients suggests that club-like cells may contribute to treatment resistance.

Antti Kiviaho
Sini K. Eerola
Matti Nykter
ResearchOpen Access16 Nov 2024
Nature Communications

Volume: 15, P: 1-16
Histochemical Appearances of Cholinesterase in the Normal Sciatic Nerve and the Changes which Occur after Nerve Section

R. S. SNELL
Research24 Aug 1957
Nature

Volume: 180, P: 378-379
Spiral and Other Growth Forms of Synthetic Diamonds: A Distinction Between Natural and Synthetic Diamond

S. TOLANSKY
I. SUNAGAWA
Research14 Nov 1959
Nature

Volume: 184, P: 1526-1527
Interferometric Studies on Synthetic Diamonds

S. TOLANSKY
I. SUNAGAWA
Research23 Jan 1960
Nature

Volume: 185, P: 203-204
Mimesis of bellflower (Campanula) by the red helleborine orchid Cephalanthera rubra

L. Anders Nilsson
Research27 Oct 1983
Nature

Volume: 305, P: 799-800
Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids

The generation of primary organoids, from fetal fluid-derived epithelial stem or progenitor cells, offers the possibility of modeling different developing tissues during gestation, even beyond the limits of pregnancy termination.

Mattia Francesco Maria Gerli
Giuseppe Calà
Paolo De Coppi
ResearchOpen Access04 Mar 2024
Nature Medicine

Volume: 30, P: 875-887
Age-specific nasal epithelial responses to SARS-CoV-2 infection

Age-specific differences upon SARS-CoV-2 infection are marked by emergence of goblet 2 inflammatory cells expressing antiviral interferon stimulating genes in paediatric nasal cultures, and basaloid-like cells with increased viral spread in cultures from older adults.

Maximillian N. J. Woodall
Ana-Maria Cujba
Claire M. Smith
ResearchOpen Access15 Apr 2024
Nature Microbiology

Volume: 9, P: 1293-1311
Local and systemic responses to SARS-CoV-2 infection in children and adults

Mechanisms explaining the milder clinical syndrome that is observed in children with SARS-CoV-2 infection.

Masahiro Yoshida
Kaylee B. Worlock
Kerstin B. Meyer
ResearchOpen Access22 Dec 2021
Nature

Volume: 602, P: 321-327
Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1

Deanna S. Smith
Martin Niethammer
Li-Huei Tsai
Research29 Sept 2000
Nature Cell Biology

Volume: 2, P: 767-775
Surface versus Intracellular Polarization of Cortical Cells

ANTHONY L. F. GORMAN
Research21 Oct 1967
Nature

Volume: 216, P: 288-289
An integrated cell atlas of the lung in health and disease

A single-cell atlas of the human lungs, integrating data from 2.4 million cells from 486 individuals and including samples from healthy and diseased lungs, provides a roadmap for the generation of organ-scale cell atlases.

Lisa Sikkema
Ciro Ramírez-Suástegui
Fabian J. Theis
ResearchOpen Access08 Jun 2023
Nature Medicine

Volume: 29, P: 1563-1577
Single-Cell Isolation and Preservation of Bacterial Cultures

J. E. DeVAY
W. C. SCHNATHORST
Research24 Aug 1963
Nature

Volume: 199, P: 775-777
Rapid and modifiable neurotransmitter receptor dynamics at a neuronal synapse in vivo

In vivo, synaptic receptor densities were maintained over minutes by a rapid exchange with nonsynaptic receptor pools and over hours through turnover. These changes and receptor dynamics may represent the initial phases of synaptic efficacy modulation before eventual structural modification involving spine growth or retraction.

Corey M McCann
Juan Carlos Tapia
Jeff W Lichtman
Research22 Jun 2008
Nature Neuroscience

Volume: 11, P: 807-815
Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring

Disruption of neocortical circuitry and architecture causes neurodevelopmental disorders. Here the authors find that migration and axon projection of upper layer neurons are dependent on Sema7A-Sema4D heterodimerization, and that insufficient transcription of Sema7A or incomplete glycosylation of Sema4D inhibit these processes.

Paraskevi Bessa
Andrew G. Newman
Victor Tarabykin
ResearchOpen Access16 Aug 2024
Nature Communications

Volume: 15, P: 1-19
Biological Fact and Theory

J. S. HUXLEY
Research29 Jan 1927
Nature

Volume: 119, P: 159-160
A novel CRISPR/Cas9-based iduronate-2-sulfatase (IDS) knockout human neuronal cell line reveals earliest pathological changes

Lorenzo Badenetti
Rosa Manzoli
Enrico Moro
ResearchOpen Access25 Jun 2023
Scientific Reports

Volume: 13, P: 1-11
Isotopically light carbon in diamonds from some kimberlite pipes in Lesotho

G. I. SMIRNOV
M. M. MOFOLO
I. N. IVANOVSKAYA
Research01 Apr 1979
Nature

Volume: 278, P: 630
Distribution of Nuclear Mechanical Moments

S. TOLANSKY
Research20 Apr 1935
Nature

Volume: 135, P: 620-621
Cell types of origin of the cell-free transcriptome

Cell types affected by various diseases are inferred from cell-free RNA.

Sevahn K. Vorperian
Mira N. Moufarrej
Stephen R. Quake
ResearchOpen Access07 Feb 2022
Nature Biotechnology

Volume: 40, P: 855-861
Accumulation of anchored proteins forms membrane diffusion barriers during neuronal polarization

Chieko Nakada
Kenneth Ritchie
Akihiro Kusumi
Research22 Jun 2003
Nature Cell Biology

Volume: 5, P: 626-632
Protection of tissue physicochemical properties using polyfunctional crosslinkers

Controlled tissue fixation with polyepoxides protects protein fluorescence, antigenicity, nucleic acids and tissue architecture.

Young-Gyun Park
Chang Ho Sohn
Kwanghun Chung
Research17 Dec 2018
Nature Biotechnology

Volume: 37, P: 73-83
Solar Prominences and Terrestrial Magnetism

WILLIAM J. S. LOCKYER
News19 Feb 1903
Nature

Volume: 67, P: 377-379
An atlas of nano-enabled neural interfaces

This Review highlights the progress made so far in engineering nanomaterials for neurotechnology applications, from neuron signal sensing and modulation to brain stimulation, with an outlook on what these technologies can enable in the future.

Héctor Acarón Ledesma
Xiaojian Li
Bozhi Tian
Reviews03 Jul 2019
Nature Nanotechnology

Volume: 14, P: 645-657
An electrophysiological study of the hippocampus of the ‘reeler’ mutant mouse

T. V. P. BLISS
S. H. CHUNG
Research08 Nov 1974
Nature

Volume: 252, P: 153-155
The corticomotoneurone connection is normal in Parkinson's disease

J. P. R. Dick
J. M. A. Cowan
C. D. Marsden
Research02 Aug 1984
Nature

Volume: 310, P: 407-409
Stimulus onset quenches neural variability: a widespread cortical phenomenon

The authors measured the variability of neuronal responses across a large number of datasets and cortical areas. They found that variability decreased in response to all stimuli tested, whether the animal was awake, behaving or anesthetized, suggesting that the stabilization of cortex in response to an input is a general cortical property.

Mark M Churchland
Byron M Yu
Krishna V Shenoy
Research21 Feb 2010
Nature Neuroscience

Volume: 13, P: 369-378
Facilitation of a dendritic calcium conductance by 5-hydroxytryptamine in the substantia nigra

S. Nedergaard
J. P. Bolam
S. A. Greenfield
Research12 May 1988
Nature

Volume: 333, P: 174-177
Organic mixed conductors for bioinspired electronics

Current technologies of bioinspired and neuromorphic electronics still lack a universal framework for integration into everyday life. This Perspective highlights how bioinspired electronics with soft electrochemical matter based on organic mixed conductors can potentially enable the integration of diverse forms of intelligence everywhere.

P. Gkoupidenis
Y. Zhang
Y. van de Burgt
Reviews22 Dec 2023
Nature Reviews Materials

Volume: 9, P: 134-149
Field effects trigger post-anodal rebound excitation in vertebrate CNS

Donald S. Faber
Henri Korn
Research27 Oct 1983
Nature

Volume: 305, P: 802-804
Targeted intracellular voltage recordings from dendritic spines using quantum-dot-coated nanopipettes

Dendritic spine voltages are recorded directly using quantum-dot-coated nanopipette electrodes under two-photon visualization, demonstrating that spines receive large synaptic potentials.

Krishna Jayant
Jan J. Hirtz
Rafael Yuste
Research12 Dec 2016
Nature Nanotechnology

Volume: 12, P: 335-342
Shorter axon initial segments do not cause repetitive firing impairments in the adult presymptomatic G127X SOD-1 Amyotrophic Lateral Sclerosis mouse

V. S. Bonnevie
K. P. Dimintiyanova
C. F. Meehan
ResearchOpen Access28 Jan 2020
Scientific Reports

Volume: 10, P: 1-16
On the Simplest Continuous Manifoldness of Two Dimensions and of Finite Extent

F. W. FRANKLAND
Research24 Jun 1880
Nature

Volume: 22, P: 170-171
Spatial Distribution of Old and New Chromatid Sub-units and Frequency of Chromatid Exchanges in Induced Human Lymphocyte Endoreduplications

B. HERREROS
F. GIANNELLI
Research21 Oct 1967
Nature

Volume: 216, P: 286-288
Plasma membrane expansion: a neuron's Herculean task

Neuronal growth and regeneration require the continuous synthesis and insertion of membrane. Pfenninger reviews our current understanding of the mechanisms involved in generating and maintaining the neuron's huge surface membrane.

Karl H. Pfenninger
Reviews04 Mar 2009
Nature Reviews Neuroscience

Volume: 10, P: 251-261
Glutamate locally activates dendritic outputs of thalamic interneurons

Charles L. Cox
Qiang Zhou
S. Murray Sherman
Research30 Jul 1998
Nature

Volume: 394, P: 478-482
Ultra-low power neuromorphic obstacle detection using a two-dimensional materials-based subthreshold transistor

Kartikey Thakar
Bipin Rajendran
Saurabh Lodha
ResearchOpen Access18 Sept 2023
npj 2D Materials and Applications

Volume: 7, P: 1-10
Observation of void formation patterns in SnAg films undergoing electromigration and simulation using random walk methods

Zhi Jin
Yu-An Shen
Hiroshi Nishikawa
ResearchOpen Access21 Apr 2021
Scientific Reports

Volume: 11, P: 1-12
Information processing in the axon

Dominique Debanne
Reviews01 Apr 2004
Nature Reviews Neuroscience

Volume: 5, P: 304-316
Color and cellular selectivity of retinal ganglion cell subtypes through frequency modulation of electrical stimulation

Javad Paknahad
Kyle Loizos
Gianluca Lazzi
ResearchOpen Access04 Mar 2021
Scientific Reports

Volume: 11, P: 1-13
The effect of material defects on resonant spin wave modes in a nanomagnet

Md Ahsanul Abeed
Sourav Sahoo
Supriyo Bandyopadhyay
ResearchOpen Access12 Nov 2019
Scientific Reports

Volume: 9, P: 1-10
Degradation of Cu nanowires in a low-reactive plasma environment

Diego S. R. Coradini
Matheus A. Tunes
Stefan Pogatscher
ResearchOpen Access05 Nov 2020
npj Materials Degradation

Volume: 4, P: 1-8
Alzheimer's disease and Aβ toxicity: from top to bottom

David H. Small
Su San Mok
Joel C. Bornstein
Reviews01 Aug 2001
Nature Reviews Neuroscience

Volume: 2, P: 595-598
A Novel Model of Murine Mucopolysaccharidosis Type VII due to an Intracisternal A Particle Element Transposition into the β-Glucuronidase Gene: Clinical and Pathologic Findings

Carole Vogler
Beth Levy
Jane Barker
Research01 Mar 2001
Pediatric Research

Volume: 49, P: 342-348

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