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A modular strategy for extracellular vesicle-mediated CRISPR-Cas9 delivery through aptamer-based loading and UV-activated cargo release

CRISPR-Cas9 technology holds the potential to treat a wide spectrum of genetic diseases. Here, the authors describe a modular platform for extracellular vesicle-based Cas9 delivery, using MS2-based RNA-binding domains and UV-cleavable linkers, suitable for various Cas9-based moieties.

Omnia M. Elsharkasy
Charlotte V. Hegeman
Olivier G. de Jong
ResearchOpen Access21 Nov 2025
Nature Communications

Volume: 16, P: 1-18
Liposomal encapsulation enhances the antitumour efficacy of the vascular disrupting agent ZD6126 in murine B16.F10 melanoma

M H A M Fens
K J Hill
R M Schiffelers
ResearchOpen Access16 Sept 2008
British Journal of Cancer

Volume: 99, P: 1256-1264
Prospects for RNA delivery with nanotechnologies

S L Hart
Editorial30 Mar 2017
Gene Therapy

Volume: 24, P: 121
The effect of an increased free fatty acid concentration on thermogenesis and substrate oxidation in obese and lean men

SLH Schiffelers
WHM Saris
MA van Baak
Research25 Jan 2001
International Journal of Obesity

Volume: 25, P: 33-38
Nanotechnology approaches for global infectious diseases

This Review outlines the potential applications of nanotechnology-based treatments for infectious diseases, with a specific focus on the progress and challenges in developing nanomedicines against HIV, tuberculosis and malaria.

Ameya R. Kirtane
Malvika Verma
Giovanni Traverso
Reviews22 Mar 2021
Nature Nanotechnology

Volume: 16, P: 369-384
The fluid membrane determines mechanics of erythrocyte extracellular vesicles and is softened in hereditary spherocytosis

Red blood cell disorders are often accompanied by increased release of extracellular vesicles (EVs), but their structural and mechanical properties are not fully understood. Here, the authors show that red blood cell EVs show liposome-like mechanical features and are softened in blood disorder patients.

Daan Vorselen
Susan M. van Dommelen
Wouter H. Roos
ResearchOpen Access23 Nov 2018
Nature Communications

Volume: 9, P: 1-9
Low density lipoprotein and liposome mediated uptake and cytotoxic effect of N⁴-octadecyl-1-β-D-arabinofuranosylcytosine in Daudi lymphoma cells

S K M Koller-Lucae
H Schott
R A Schwendener
ResearchOpen Access25 Jun 1999
British Journal of Cancer

Volume: 80, P: 1542-1549
Association of a beta-2 adrenoceptor (ADRB2) gene variant with a blunted in vivo lipolysis and fat oxidation

J W E Jocken
E E Blaak
W H M Saris
Research28 Nov 2006
International Journal of Obesity

Volume: 31, P: 813-819
Lipolytic and nutritive blood flow response to β-adrenoceptor stimulation in situ in subcutaneous abdominal adipose tissue in obese men

S L H Schiffelers
J A P Akkermans
E E Blaak
Research14 Feb 2003
International Journal of Obesity

Volume: 27, P: 227-231

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A modular strategy for extracellular vesicle-mediated CRISPR-Cas9 delivery through aptamer-based loading and UV-activated cargo release

Liposomal encapsulation enhances the antitumour efficacy of the vascular disrupting agent ZD6126 in murine B16.F10 melanoma

Prospects for RNA delivery with nanotechnologies

The effect of an increased free fatty acid concentration on thermogenesis and substrate oxidation in obese and lean men

Nanotechnology approaches for global infectious diseases

The fluid membrane determines mechanics of erythrocyte extracellular vesicles and is softened in hereditary spherocytosis

Low density lipoprotein and liposome mediated uptake and cytotoxic effect of N⁴-octadecyl-1-β-D-arabinofuranosylcytosine in Daudi lymphoma cells

Association of a beta-2 adrenoceptor (ADRB2) gene variant with a blunted in vivo lipolysis and fat oxidation

Lipolytic and nutritive blood flow response to β-adrenoceptor stimulation in situ in subcutaneous abdominal adipose tissue in obese men

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