Nature Search

Opportunities and challenges with the implementation of normothermic machine perfusion in kidney transplantation

Normothermic machine perfusion could prolong and/or improve preservation of kidneys in transplantation, but the technology has yet to reach clinical realization. Here, the authors show the hurdles, but also the solutions, for this technology to become a reality in transplantation and beyond.

Ton J. Rabelink
Sarah Hosgood
Stefan Schneeberger
ReviewsOpen Access25 Jul 2025
Nature Communications

Volume: 16, P: 1-13
Enzymatic conversion of human blood group A kidneys to universal blood group O

ABO blood group compatibility restrictions limit the availability of organs for patients awaiting transplantation. Here, the authors show the rapid enzymatic removal of blood group A antigens from the vasculature of human kidneys using normothermic and hypothermic machine perfusion technologies to make universal blood group O organs for transplantation.

Serena MacMillan
Sarah A. Hosgood
Michael L. Nicholson
ResearchOpen Access30 Mar 2024
Nature Communications

Volume: 15, P: 1-14
Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Jianxin Shi
Kouya Shiraishi
Qing Lan
ResearchOpen Access26 May 2023
Nature Communications

Volume: 14, P: 1-17
Normothermic machine perfusion versus static cold storage in donation after circulatory death kidney transplantation: a randomized controlled trial

In an open-label, randomized controlled trial, normothermic machine perfusion of kidneys from donation after circulatory death was found to be feasible and safe but did not reduce the rate of delayed graft function compared to static cold storage.

Sarah A. Hosgood
Christopher J. Callaghan
Michael L. Nicholson
ResearchOpen Access25 May 2023
Nature Medicine

Volume: 29, P: 1511-1519
Monobody adapter for functional antibody display on nanoparticles for adaptable targeted delivery applications

Targeted nanoparticle delivery to sites of interest is important for targeted therapeutics. Here, the authors improve the targeting efficiency of antibodies on nanoparticles using a monobody adapter to correctly orientate the antibody to preserve targeting function and demonstrate application in targeting the vascular endothelium of human kidneys.

C. Albert
L. Bracaglia
G. T. Tietjen
ResearchOpen Access11 Oct 2022
Nature Communications

Volume: 13, P: 1-13
Genetic divergence under uniform selection. III. Selection for knockdown resistance to ethanol in Drosophila pseudoobscura populations and their replicate lines

Ary A Hoffmann
Frederick M Cohan
Research01 Jun 1987
Heredity

Volume: 58, P: 425-433
High leukocyte mitochondrial DNA content contributes to poor prognosis in glioma patients through its immunosuppressive effect

Y Chen
J Zhang
J Xing
ResearchOpen Access28 May 2015
British Journal of Cancer

Volume: 113, P: 99-106
Exposure to benzene and other hydrocarbons and risk of bladder cancer among male offshore petroleum workers

Nita K. Shala
Jo S. Stenehjem
Tom K. Grimsrud
ResearchOpen Access18 Jul 2023
British Journal of Cancer

Volume: 129, P: 838-851
Differential effects of smoking on lung cancer mortality before and after household stove improvement in Xuanwei, China

K-M Lee
R S Chapman
Q Lan
ResearchOpen Access20 Jul 2010
British Journal of Cancer

Volume: 103, P: 727-729
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli
Massimo Bogliolo
Paolo Peterlongo
ResearchOpen Access01 Nov 2019
npj Breast Cancer

Volume: 5, P: 1-14
Mendelian randomization analysis of arsenic metabolism and pulmonary function within the Hispanic Community Health Study/Study of Latinos

Molly Scannell Bryan
Tamar Sofer
Maria Argos
ResearchOpen Access29 Jun 2021
Scientific Reports

Volume: 11, P: 1-11

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Opportunities and challenges with the implementation of normothermic machine perfusion in kidney transplantation

Enzymatic conversion of human blood group A kidneys to universal blood group O

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Normothermic machine perfusion versus static cold storage in donation after circulatory death kidney transplantation: a randomized controlled trial

Monobody adapter for functional antibody display on nanoparticles for adaptable targeted delivery applications

Genetic divergence under uniform selection. III. Selection for knockdown resistance to ethanol in Drosophila pseudoobscura populations and their replicate lines

High leukocyte mitochondrial DNA content contributes to poor prognosis in glioma patients through its immunosuppressive effect

Exposure to benzene and other hydrocarbons and risk of bladder cancer among male offshore petroleum workers

Differential effects of smoking on lung cancer mortality before and after household stove improvement in Xuanwei, China

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Mendelian randomization analysis of arsenic metabolism and pulmonary function within the Hispanic Community Health Study/Study of Latinos

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