To achieve chemoselective additions of organometallics to carbonyls, it is important to consider the combination of acylating agent and organometallic as a reactive pair rather than either one in isolation. Here, a chemoselective, controlled and general methodology for the conversion of secondary amides to ketones and ketimines is described.
- William S. Bechara
- Guillaume Pelletier
- André B. Charette
