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Showing 51–65 of 65 results

Advanced filters: Author: S. Goldring Clear advanced filters

Integrin signalling in joint development, homeostasis and osteoarthritis

Integrins are involved in joint tissue development and homeostasis, and perturbations in the availability of integrin ligands or in downstream integrin signalling are linked to the pathogenesis of osteoarthritis (OA). This Review discusses current evidence and future perspectives for therapeutically targeting integrins in OA.

Michael Z. Miao
Janice S. Lee
Richard F. Loeser
Reviews16 Jul 2024
Nature Reviews Rheumatology

Volume: 20, P: 492-509
A polymorphic duplicated locus for cytosolic PGI segregating in sheep’s fescue (Festuca ovina L.)

Lena Ghatnekar
Research01 Oct 1999
Heredity

Volume: 83, P: 451-459
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

Current preclinical models poorly predict the potential of a new drug candidate to cause drug-induced liver injury (DILI) in humans. Here, Park and colleagues discuss current understanding of the mechanisms mediating DILI and, through an academic–industry collaboration, propose a roadmap for the development of predictive preclinical models of human DILI.

Richard J. Weaver
Eric A. Blomme
B. Kevin Park
Reviews20 Nov 2019
Nature Reviews Drug Discovery

Volume: 19, P: 131-148
Child Neurology in the 20th Century

Stephen Ashwal
Robert Rust
Research01 Feb 2003
Pediatric Research

Volume: 53, P: 345-361
PKG and PKA Signaling in LTP at GABAergic Synapses

Fereshteh S Nugent
Jason L Niehaus
Julie A Kauer
Research04 Feb 2009
Neuropsychopharmacology

Volume: 34, P: 1829-1842
Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity

Shiva S. Forootan
Fiona E. Mutter
Ian M. Copple
ResearchOpen Access22 Nov 2017
Scientific Reports

Volume: 7, P: 1-11
Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome

R. Eakins
J. Walsh
B. K. Park
ResearchOpen Access26 Nov 2015
Scientific Reports

Volume: 5, P: 1-13
Molecular analysis of chromium and cobalt-related toxicity

Brian Scharf
Cristina C. Clement
Laura Santambrogio
ResearchOpen Access17 Jul 2014
Scientific Reports

Volume: 4, P: 1-12
Joint-on-chip platforms: entering a new era of in vitro models for arthritis

In this Review, Paggi et al. discuss the requirements and challenges in engineering a joint-on-chip device, propose an architecture for such a model of the joint and highlight the potential for these platforms to further advance insight into arthritic diseases and facilitate drug development.

Carlo Alberto Paggi
Liliana Moreira Teixeira
Marcel Karperien
Reviews20 Jan 2022
Nature Reviews Rheumatology

Volume: 18, P: 217-231
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms

Christopher Pittenger
Ronald S Duman
Reviews12 Sept 2007
Neuropsychopharmacology

Volume: 33, P: 88-109
Effects of local climate on loggerhead hatchling production in Brazil: Implications from climate change

Natalie Montero
Pilar Santidrian Tomillo
Mariana M. P. B. Fuentes
ResearchOpen Access20 Jun 2019
Scientific Reports

Volume: 9, P: 1-12
Hypoxia reduces adenoviral replication in cancer cells by downregulation of viral protein expression

T Pipiya
H Sauthoff
J G Hay
Research03 Feb 2005
Gene Therapy

Volume: 12, P: 911-917
Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies

Lauren Scarfe
Nathalie Brillant
B. Kevin Park
ReviewsOpen Access19 Oct 2017
npj Regenerative Medicine

Volume: 2, P: 1-13
Extracellular matrix-induced transforming growth factor-β receptor signaling dynamics

N Garamszegi
S P Garamszegi
S P Scully
Research25 Jan 2010
Oncogene

Volume: 29, P: 2368-2380
Modification of the p53 transgene of a replication-competent adenovirus prevents mdm2- and E1b-55kD-mediated degradation of p53

H Sauthoff
T Pipiya
J G Hay
Research10 Feb 2006
Cancer Gene Therapy

Volume: 13, P: 686-695

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