In multiple sclerosis, the ability of clinicians to provide a prognosis for a patient and the design and interpretation of clinical trials both rely heavily on prognostic factors identified from systematic natural history studies. Degenhardt and colleagues outline their criteria for well-designed natural history studies in multiple sclerosis and review the prognostic factors identified from such investigations for the various forms of the disease.
- Alexandra Degenhardt
- Sreeram V. Ramagopalan
- George C. Ebers
