Nature Search

Reversible spin-optical interface in luminescent organic radicals

We report organic molecules showing both efficient luminescence and near-unity generation yield of excited states with high spin multiplicity, simultaneously supporting a high efficiency of initialization, spin manipulations and light-based readout at room temperature.

Sebastian Gorgon
Kuo Lv
Emrys W. Evans
ResearchOpen Access16 Aug 2023
Nature

Volume: 620, P: 538-544
Toward accurate rheological prediction of lunar regolith simulant pastes via constitutive modeling

Amalia K. Ioannou
Pavlos S. Stephanou
ResearchOpen Access02 Feb 2026
npj Space Exploration

Volume: 2, P: 1-8
A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
Integrating a host biomarker with a large language model for diagnosis of lower respiratory tract infection

In this study, the authors show that integrating a host gene biomarker with a large language model (LLM) improved lower respiratory tract infections diagnosis in a cohort of critically ill patients. The LLM plus biomarker outperformed the diagnosis made by the initial medical team and each component alone.

Hoang Van Phan
Natasha Spottiswoode
Charles R. Langelier
ResearchOpen Access16 Dec 2025
Nature Communications

Volume: 16, P: 1-8
An expanded registry of candidate cis-regulatory elements

The existing ENCODE registry of candidate human and mouse cis-regulatory elements is expanded with the addition of new ENCODE data, integrating new functional data as well as new cell and tissue types.

Jill E. Moore
Henry E. Pratt
Zhiping Weng
ResearchOpen Access07 Jan 2026
Nature

P: 1-10
Chlorinated bis-4-hydroxycoumarins suppress flavivirus replication by inhibiting dengue virus type 2 translation and replication

Naphat Loeanurit
Thi-Hong-Truc Phan
Siwaporn Boonyasuppayakorn
ResearchOpen Access16 Jan 2026
Scientific Reports

P: 1-17
Determination of the spin and parity of all-charm tetraquarks

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

A. Hayrapetyan
V. Makarenko
A. Snigirev
ResearchOpen Access03 Dec 2025
Nature

Volume: 648, P: 58-63
Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity

Chaperone-mediated autophagy (CMA) is often dysregulated in cancer, but its mechanisms remain unclear. This study reveals that MST4- mediated LAMP2A phosphorylation regulates CMA by stabilizing lysosomal LAMP2A, thereby promoting GBM tumorigenicity and immune evasion.

Yonghua Li
Min Sheng
Tianzhi Huang
ResearchOpen Access13 Dec 2025
Nature Communications

Volume: 17, P: 1-26
Chemical Investigation of Hæmoglobin F from an Individual with Persistent Fœtal Hæmoglobin

W. A. SCHROEDER
PHILLIP STURGEON
WILLIAM R. BERGREN
Research24 Mar 1962
Nature

Volume: 193, P: 1161-1162
Biosynthetic Labelling of Mammalian Insulins in vitro

K. W. TAYLOR
D. G. PARRY
G. HOWARD SMITH
Research12 Sept 1964
Nature

Volume: 203, P: 1144-1145
Chinese Astronomical Clockwork

JOSEPH NEEDHAM
WANG LING
DEREK J. PRICE
Research31 Mar 1956
Nature

Volume: 177, P: 600-602
X-Ray Crystal Data on Fluorescent Substance from Bovine Liver

S. FURBERG
Research28 May 1966
Nature

Volume: 210, P: 919
Organic Acids as Sources of Carbon for Ethylene Production

M. S. GIBSON
Research30 May 1964
Nature

Volume: 202, P: 902-903
Rational design of potent sialidase-based inhibitors of influenza virus replication

Mark von Itzstein
Wen-Yang Wu
Charles R. Penn
Research03 Jun 1993
Nature

Volume: 363, P: 418-423
Timing the evolution of antioxidant enzymes in cyanobacteria

How early photosynthesizers managed oxidative stress remains relatively unresolved. Analyses of enzymes dealing with reactive oxygen species traces the evolutionary history of superoxide dismutases and finds evidence of CuZnSOD in the ancestor of all cyanobacteria, dating back to the Archaean.

Joanne S. Boden
Kurt O. Konhauser
Patricia Sánchez-Baracaldo
ResearchOpen Access06 Aug 2021
Nature Communications

Volume: 12, P: 1-12
Effect of Certain Phenolic Acids on the Elongation of Avena First Internodes in the Presence of Auxins and Tryptophan

J. H. M. HENDERSON
J. P. NITSCH
Research25 Aug 1962
Nature

Volume: 195, P: 780-782
Release of Prostaglandin E₁ from the Rat Stomach

A. BENNETT
C. A. FRIEDMANN
J. R. VANE
Research02 Dec 1967
Nature

Volume: 216, P: 873-876
Reemergence of high-T_c superconductivity in the (Li_1-xFe_x)OHFe_1-ySe under high pressure

The understanding of the reemergence of pressure induced superconductivity in alkali-metal intercalated FeSe is hampered by sample complexities. Here, Sun et al. report the electronic properties of (Li_1–xFe_x)OHFe_1–ySe single crystal not only in the reemerged superconducting state but also in the normal state.

J. P. Sun
P. Shahi
J.-G. Cheng
ResearchOpen Access25 Jan 2018
Nature Communications

Volume: 9, P: 1-7
Presence in Lipoproteins from Human Serum of a Crystalline Blue Fluorescent Substance of Unknown Structure Isolated from Bovine Liver

P. LALAND
J. O. ALVSAKER
N. THORSDALEN
Research28 May 1966
Nature

Volume: 210, P: 917-919
Dating Alphaproteobacteria evolution with eukaryotic fossils

Dating early bacterial evolution is challenging due to the limited bacterial fossil record. Here Wang and Luo use the close evolutionary relationship between Alphaproteobacteria and mitochondria to leverage the eukaryotic fossil record in dating Alphaproteobacteria origin and diversification.

Sishuo Wang
Haiwei Luo
ResearchOpen Access03 Jun 2021
Nature Communications

Volume: 12, P: 1-9
scRNA-seq reveals persistent aberrant differentiation of nasal epithelium driven by TNFα and TGFβ in post-COVID syndrome

In this work, authors apply single-cell transcriptomics to nasal biopsies from post-COVID syndrome patients, revealing chronic inflammation driven by TNFα and TGFβ, alongside persistent airway epithelial remodelling in the absence of viral load.

K. D. Reddy
Y. Maluje
A. Fähnrich
ResearchOpen Access28 Oct 2025
Nature Communications

Volume: 16, P: 1-13
Foundation models enable wearable signal screening for cardiovascular disease among people living with HIV

Mesinovic et al. use AI foundation models to implement heart disease screening in people living with HIV in Vietnam, relying on low-cost wearable sensors. This approach achieves promising discriminative ability and requires only lightweight local training, potentially enabling affordable screening in resource-limited clinics.

Munib Mesinovic
Hai Ho Bich
Tingting Zhu
ResearchOpen Access16 Jan 2026
Communications Medicine

Volume: 6, P: 1-11
Low Doses of 17β-Estradiol Rapidly Improve Learning and Increase Hippocampal Dendritic Spines

Anna Phan
Christopher S Gabor
Elena Choleris
Research06 Jun 2012
Neuropsychopharmacology

Volume: 37, P: 2299-2309
Effect of Multi-site Mutation to Colicine Resistance on Recombination and Segregation in Escherichia coli

J. P. GRATIA
Research29 Dec 1962
Nature

Volume: 196, P: 1337-1338
Deep reinforcement learning-based intrusion detection scheme for software-defined networking

R. Kanimozhi
P. S. Ramesh
ResearchOpen Access05 Nov 2025
Scientific Reports

Volume: 15, P: 1-17
DNA targeting by compact Cas9d and its resurrected ancestor

Ocampo et al. present several structures and the biochemical characterization of a compact Cas9 nuclease, shedding light on how these enzymes function and evolve.

Rodrigo Fregoso Ocampo
Jack P. K. Bravo
David W. Taylor
ResearchOpen Access07 Jan 2025
Nature Communications

Volume: 16, P: 1-16
Bennu and Ryugu constituents from samples IR analyses and potential source of terrestrial planets’ ingredients

Analyses performed on the Ryugu and Bennu samples from the centimetre down to the sub-millimetre scale reveal that they share most near-IR spectral properties, implying similar initial material and evolution processes, yet not strictly identical.

C. Pilorget
T. Okada
K. Yogata
ResearchOpen Access04 Nov 2025
Nature Communications

Volume: 16, P: 1-10
Cell signalling at the shoot meristem

Steven E. Clark
Reviews01 Apr 2001
Nature Reviews Molecular Cell Biology

Volume: 2, P: 276-284
Prognostic role of undetectable ablation thyroglobulin and follow-up thyroglobulin in patients with thyroid cancer

Sophie Leboulleux
Comments & Opinion24 Jun 2008
Nature Clinical Practice Endocrinology & Metabolism

Volume: 4, P: 436-437
Localization of Inducible Nitric Oxide Synthase to Mast Cells During Ischemia/Reperfusion Injury of Skeletal Muscle

Aurora Messina
Kenneth R Knight
Alastair G Stewart
Research01 Mar 2000
Laboratory Investigation

Volume: 80, P: 423-431
Similar modes of polypeptide recognition by export chaperones in flagellar biosynthesis and type III secretion

Artem G Evdokimov
Jason Phan
David S Waugh
Research07 Sept 2003
Nature Structural & Molecular Biology

Volume: 10, P: 789-793
Durability and service life prediction of fly ash based geopolymer high performance concrete under extreme environmental conditions

Vikrant S. Vairagade
ResearchOpen Access04 Dec 2025
Scientific Reports

Volume: 15, P: 1-23
CEACAM1 as a mediator of B-cell receptor signaling in mantle cell lymphoma

Pathological B-cell receptor (BCR) signaling is a key driver of mantle cell lymphoma tumorigenesis. Here, the authors discover that CEACAM1, an immunoglobulin-like transmembrane protein, is essential for a subset of mantle cell lymphoma through activation of the BCR.

Serene Xavier
Vivian Nguyen
Vu N. Ngo
ResearchOpen Access29 May 2025
Nature Communications

Volume: 16, P: 1-18
Oxytocin Attenuates Amygdala Reactivity to Fear in Generalized Social Anxiety Disorder

Izelle Labuschagne
K Luan Phan
Pradeep J Nathan
Research18 Aug 2010
Neuropsychopharmacology

Volume: 35, P: 2403-2413
Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients

Solid organ transplant recipients are at increased risk of infectious disease and have unique molecular pathophysiology. Here the authors use host-microbe profiling to assess SARS-CoV-2 infection and immunity in solid organ transplant recipients, showing enhanced viral abundance, impaired clearance, and increased expression of innate immunity genes.

Harry Pickering
Joanna Schaenman
Charles R. Langelier
ResearchOpen Access10 Jan 2025
Nature Communications

Volume: 16, P: 1-16
Common origin of sterol biosynthesis points to a feeding strategy shift in Neoproterozoic animals

Sterane molecular fossils are used to compliment evidence from the fossil record. Here, the authors use a molecular clock to explore the origins of the smt gene, tracing the loss of sterol synthesis to dietary shifts in animals at the end-Neoproterozoic.

T. Brunoir
C. Mulligan
D. A. Gold
ResearchOpen Access01 Dec 2023
Nature Communications

Volume: 14, P: 1-8
Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

Roland Tisch
Xiao-Dong Yang
Hugh O. McDevitt
Research04 Nov 1993
Nature

Volume: 366, P: 72-75
Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

Daniel L. Kaufman
Michael Clare-Salzler
Paul V. Lehmann
Research04 Nov 1993
Nature

Volume: 366, P: 69-72
Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia

In this work, authors assess airway microbiome dynamics to show bacterial pneumonia in critically ill COVID-19 patients is significantly associated with death, corticosteroid treatment, disruption of the lung microbiome and a distinct pulmonary host response.

Natasha Spottiswoode
Alexandra Tsitsiklis
Charles R. Langelier
ResearchOpen Access29 Oct 2024
Nature Communications

Volume: 15, P: 1-16
Selective facet joint and interlaminar fusion using unilateral biportal endoscopy for thoracolumbar compression fractures: a comparative study

Bo Zheng
Peng Li
Ze-Bi He
ResearchOpen Access27 Jul 2025
Scientific Reports

Volume: 15, P: 1-14
Memory B cell responses induced by pneumococcal conjugate vaccine schedules with fewer doses: analysis of a randomised-controlled trial in Viet Nam

As part of a randomized controlled trial in Viet Nam, this study finds that pneumococcal-specific memory B cells (B_mem) are higher following a 1 + 1 compared to a 0 + 1 pneumococcal conjugate vaccine (PCV) schedule and higher for PCV13 compared to PCV10. B_mem did not wane as rapidly as IgG by 24 months of age.

Darren Suryawijaya Ong
Thanh V. Phan
Paul Vincent Licciardi
ResearchOpen Access14 Aug 2024
Nature Communications

Volume: 15, P: 1-10
Specific CD4⁺ T cell phenotypes associate with bacterial control in people who ‘resist’ infection with Mycobacterium tuberculosis

Seshadri, Davis and colleagues show that individuals who do not develop an infection with Mycobacterium tuberculosis (Mtb), despite exposure to the bacteria and expansion of CD4⁺ T cell clones specific to Mtb antigens, show enrichment of T_H17 cell and T regulatory functional programs.

Meng Sun
Jolie M. Phan
Chetan Seshadri
ResearchOpen Access12 Jul 2024
Nature Immunology

Volume: 25, P: 1411-1421
Development of 5-Hydroxytryptophan Decarboxylase Activity in Rat Kidney

IRENE HUANG
SHEILA TANNENBAUM
DAVID YI-YUNG HSIA
Research28 May 1960
Nature

Volume: 186, P: 717-718
Auxin Activity in Ether-insoluble Fractions of Extracts of Rhubarb Petioles

B. E. S. GUNNING
Research18 Nov 1961
Nature

Volume: 192, P: 661-662
Plasma Mast Cells

G. H. HOTTENDORF
S. W. NIELSEN
A. J. KENYON
Research19 Nov 1966
Nature

Volume: 212, P: 829-830
Identification of epithelial stromal interaction 1 as a novel effector downstream of Krüppel-like factor 8 in breast cancer invasion and metastasis

T Li
H Lu
J Zhao
Research07 Oct 2013
Oncogene

Volume: 33, P: 4746-4755
Kinetics of Acetylsalicylic Acid Disposition in Man

M. ROWLAND
S. RIEGELMAN
E. J. EYRING
Research22 Jul 1967
Nature

Volume: 215, P: 413-414
Neoadjuvant triplet immune checkpoint blockade in newly diagnosed glioblastoma

A patient with newly diagnosed glioblastoma was safely treated with neoadjuvant nivolumab, relatlimab and ipilimumab before maximal resection, with comprehensive immune profiling showing the induction of overall immune activation early during treatment. The patient had no definitive evidence of recurrence at 17 months after treatment.

Georgina V. Long
Elena Shklovskaya
Helen Rizos
ResearchOpen Access27 Feb 2025
Nature Medicine

Volume: 31, P: 1557-1566
Effect of Tryptophan Analogues on Reversion of a Tryptophan-requiring Strain of Escherichia coli

N. M. SCHWARTZ
B. S. STRAUSS
Research27 Sept 1958
Nature

Volume: 182, P: 888
High-plex imaging of RNA and proteins at subcellular resolution in fixed tissue by spatial molecular imaging

Hundreds of RNAs and proteins are imaged in fixed tissue at subcellular resolution.

Shanshan He
Ruchir Bhatt
Joseph M. Beechem
Research06 Oct 2022
Nature Biotechnology

Volume: 40, P: 1794-1806

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