Nature Search

Reduction in mobility and COVID-19 transmission

Social distancing policies aiming to reduce COVID-19 transmission have been reflected in reductions in human mobility. Here, the authors show that reduced mobility is correlated with decreased transmission, but that this relationship weakened over time as social distancing measures were relaxed.

Pierre Nouvellet
Sangeeta Bhatia
Christl A. Donnelly
ResearchOpen Access17 Feb 2021
Nature Communications

Volume: 12, P: 1-9
Homozygous HOXA1 mutations disrupt human brainstem, inner ear, cardiovascular and cognitive development

Max A Tischfield
Thomas M Bosley
Elizabeth C Engle
Research11 Sept 2005
Nature Genetics

Volume: 37, P: 1035-1037
Clinical, neuroradiological and molecular characterization of cerebellar dysplasia with cysts (Poretti–Boltshauser syndrome)

Alessia Micalizzi
Andrea Poretti
Enza Maria Valente
Research02 Mar 2016
European Journal of Human Genetics

Volume: 24, P: 1262-1267
Analysis of the CaMKIIα and β splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation

Sarah G. Cook
Ashley M. Bourke
K. Ulrich Bayer
ResearchOpen Access03 Apr 2018
Scientific Reports

Volume: 8, P: 1-15
Screening of genes interacting with high myopia and neuropsychiatric disorders

Yang Liu
Yang Liu
Wen-Juan Zhuang
ResearchOpen Access26 Oct 2023
Scientific Reports

Volume: 13, P: 1-10
Brain structural features with functional priori to classify Parkinson’s disease and multiple system atrophy using diagnostic MRI

Kai Zhou
Jie Li
Qing Gao
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
Age-dependent sex differences in non-stenotic intracranial plaque of embolic stroke of undetermined source

Na Luo
Zi-Yang Shang
Hui-Sheng Chen
ResearchOpen Access24 Nov 2023
Scientific Reports

Volume: 13, P: 1-9
A clinicopathological approach to the diagnosis of dementia

The process of phenotyping and classification of dementia has improved over decades of careful clinicopathological correlation, and through the discovery ofin vivobiomarkers of disease. Elahi and Miller review the salient features of the most common dementia subtypes, emphasizing neuropathology, epidemiology, risk factors, and signature signs and symptoms.

Fanny M. Elahi
Bruce L. Miller
Reviews14 Jul 2017
Nature Reviews Neurology

Volume: 13, P: 457-476
Erratum: Calpain 3 deficiency is associated with myonuclear apoptosis and profound perturbation of the IkBa/NF-kB pathway in limb-girdle muscular dystrophy type 2A

S. Baghdiguian
M. Martin
G. Lefranc
Amendments and Corrections01 Jul 1999
Nature Medicine

Volume: 5, P: 849
Photoexcitation circular dichroism in chiral molecules

Photoexcitation circular dichroism generates an ultrafast response in chiral molecules, with a much higher sensitivity than standard circular dichroism.

S. Beaulieu
A. Comby
V. Blanchet
Research19 Feb 2018
Nature Physics

Volume: 14, P: 484-489
A shared neural basis underlying psychiatric comorbidity

Evidence from large longitudinal neuroimaging cohorts, which include genetic and behavioral data, suggest a common neural basis for symptoms seen across multiple psychiatric disorders.

Chao Xie
Shitong Xiang
Betteke Maria van Noort
ResearchOpen Access24 Apr 2023
Nature Medicine

Volume: 29, P: 1232-1242
Increased white matter glycolysis in humans with cerebral small vessel disease

This study found that cerebral small vessel disease was associated with relatively increased glycolysis in the normal-appearing white matter around lesions. Furthermore, lesions tend to develop in white matter that is less glycolytic in healthy humans.

Matthew R. Brier
Tyler Blazey
Manu S. Goyal
Research10 Nov 2022
Nature Aging

Volume: 2, P: 991-999
The cognitive neuroscience of sleep: neuronal systems, consciousness and learning

J. Allan Hobson
Edward F. Pace-Schott
Reviews01 Sept 2002
Nature Reviews Neuroscience

Volume: 3, P: 679-693
Effects of urban living environments on mental health in adults

Analyses of data from the UK Biobank reveal different urban living environments that are associated with affective, anxiety and emotional instability symptom groups and mediated by distinct neurological and genetic pathways in adults.

Jiayuan Xu
Nana Liu
George Ogoh
ResearchOpen Access15 Jun 2023
Nature Medicine

Volume: 29, P: 1456-1467
Progression trajectories from prodromal to overt synucleinopathies: a longitudinal, multicentric brain [¹⁸F]FDG-PET study

Beatrice Orso
Pietro Mattioli
Dario Arnaldi
ResearchOpen Access25 Oct 2024
npj Parkinson's Disease

Volume: 10, P: 1-10
A functional parcellation of the whole brain in high-functioning individuals with autism spectrum disorder reveals atypical patterns of network organization

Andrew S. Persichetti
Jiayu Shao
Alex Martin
ResearchOpen Access30 Sept 2024
Molecular Psychiatry

Volume: 30, P: 1518-1528
The autonomic effects of deep brain stimulation—a therapeutic opportunity

Deep brain stimulation (DBS) is currently used as an effective treatment to reduce symptoms in chronic pain and movement disorders. An inadvertent and positive side effect of this therapy is the autonomic response to DBS in terms of changes to respiratory indices, lung function, and urinary and bladder function. This Review discusses the circuitry of the autonomic nervous system and its higher control centres, and the potential for DBS as a therapy for patients with dysautonomias.

Jonathan A. Hyam
Morten L. Kringelbach
Alexander L. Green
Reviews12 Jun 2012
Nature Reviews Neurology

Volume: 8, P: 391-400
Erratum: Enterotypes of the human gut microbiome

Manimozhiyan Arumugam
Jeroen Raes
Peer Bork
Amendments and Corrections08 Jun 2011
Nature

Volume: 474, P: 666
Hierarchical imaging and computational analysis of three-dimensional vascular network architecture in the entire postnatal and adult mouse brain

This protocol uses vascular corrosion casting, hierarchical synchrotron radiation microcomputed tomography imaging and computational image analysis to assess the 3D vascular network architecture in the entire postnatal and adult mouse brain.

Thomas Wälchli
Jeroen Bisschop
Marco Stampanoni
Protocols03 Sept 2021
Nature Protocols

Volume: 16, P: 4564-4610
Glioma

This Primer by Weller and colleagues summarizes the epidemiology, pathophysiology, diagnosis and treatment of glioma in both adults and children.

Michael Weller
Patrick Y. Wen
Guido Reifenberger
Reviews09 May 2024
Nature Reviews Disease Primers

Volume: 10, P: 1-23
Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2

A rare case of cytokine release syndrome in a patient on anti-PD-1 blockade that was likely related to BNT162b2 vaccination supports prospective monitoring of patients with cancer after COVID-19 vaccine administration.

Lewis Au
Annika Fendler
Samra Turajlic
ResearchOpen Access26 May 2021
Nature Medicine

Volume: 27, P: 1362-1366
Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder

Cigdem Gelegen
Diana Cash
Ivana Rosenzweig
ResearchOpen Access13 May 2022
Scientific Reports

Volume: 12, P: 1-7
New insights into mechanisms of therapeutic effects of antimalarial agents in SLE

Antimalarial agents are mainstays in the clinical management of systemic lupus erythematosus, and have been in routine use for more than 50 years. This Review summarizes recent insights into the mechanisms of action of these agents and their clinical implications.

Daniel J. Wallace
Vineet S. Gudsoorkar
Swamy R. Venuturupalli
Reviews17 Jul 2012
Nature Reviews Rheumatology

Volume: 8, P: 522-533
Brainstem transcriptomic changes in male Wistar rats after acute stress, comparing the use of duplex specific nuclease (DSN)

Dmitriy A. Lanshakov
Ekaterina V. Sukhareva
Tatyana S. Kalinina
ResearchOpen Access19 Sept 2024
Scientific Reports

Volume: 14, P: 1-25
Childhood brain tumors: epidemiology, current management and future directions

Brain tumors are among the most common childhood cancers and are the leading cause of cancer-related childhood mortality. In this Review, Pollack and Jakacki describe the clinical presentation, diagnosis and management of childhood brain tumors, with a particular focus on how treatment of the most common subtypes of childhood brain tumors has evolved over time, and the future approaches that could lead to improved outcome for these pediatric patients.

Ian F. Pollack
Regina I. Jakacki
Reviews26 Jul 2011
Nature Reviews Neurology

Volume: 7, P: 495-506
A neural signature for the subjective experience of threat anticipation under uncertainty

The neural systems which underlie the experience of anticipated threat under uncertainty are not well understood. Here, the authors find a whole-brain signature which specifically predicts anxious anticipation.

Xiqin Liu
Guojuan Jiao
Benjamin Becker
ResearchOpen Access20 Feb 2024
Nature Communications

Volume: 15, P: 1-16
Functionnectome as a framework to analyse the contribution of brain circuits to fMRI

Nozais et al introduce a method, the Functionnectome, which comes with an open-source companion software and unravels the relationship between brain circuits and functions. Their tool combines the functional signal from fMRI with white matter circuitry anatomy to chart maps of functional white matter, providing additional avenues for studying functional networks.

Victor Nozais
Stephanie J. Forkel
Michel Thiebaut de Schotten
ResearchOpen Access02 Sept 2021
Communications Biology

Volume: 4, P: 1-12
Molecular logic of neocortical projection neuron specification, development and diversity

Understanding how each of the many diverse subtypes of neurons that make up the cortex are specified during development presents a continuing challenge for developmental neurobiologists. Macklis and colleagues describe recent advances in our understanding of the specification of cortical projection neuron subtype and area identity.

Luciano Custo Greig
Mollie B. Woodworth
Jeffrey D. Macklis
Reviews09 Oct 2013
Nature Reviews Neuroscience

Volume: 14, P: 755-769
A neural circuit for the suppression of feeding under persistent pain

Chronic pain is often accompanied by decreased appetite. The authors uncover the neuronal circuits that lead to reduced feeding in a mouse model of persistent pain, which involves cortical-to-hypothalamic glutamatergic signalling.

Hao-Di Tang
Wan-Ying Dong
Zhi Zhang
Research28 Nov 2022
Nature Metabolism

Volume: 4, P: 1746-1755
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

Lipophilic siRNA conjugates exert therapeutic activity in the mouse CNS.

Kirk M. Brown
Jayaprakash K. Nair
Vasant Jadhav
Research02 Jun 2022
Nature Biotechnology

Volume: 40, P: 1500-1508
Differential Roles of α6β2* and α4β2* Neuronal Nicotinic Receptors in Nicotine- and Cocaine-Conditioned Reward in Mice

Sarah S Sanjakdar
Pretal P Maldoon
M Imad Damaj
Research18 Jul 2014
Neuropsychopharmacology

Volume: 40, P: 350-360
A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor

Here the authors perform a gain-of-function screen and identify CDKN2C as a host factor for HBV replication, inducing cell cycle arrest and expression of HBV transcription enhancers. CDKN2C expression correlates with disease progression suggesting a potential role in HBV-induced liver disease.

Carla Eller
Laura Heydmann
Thomas F. Baumert
ResearchOpen Access01 Jun 2020
Nature Communications

Volume: 11, P: 1-17
Hematological and biochemical profiles, infection and habitat quality in an urban rat population

Ticiana Carvalho-Pereira
Gabriel G. Pedra
Federico Costa
ResearchOpen Access22 Jul 2025
Scientific Reports

Volume: 15, P: 1-8
Essential tremor

This Primer summarizes the epidemiology, diagnosis, treatment and pathophysiology of essential tremor, a movement disorder that is typically characterized by upper limb action tremor in the absence of other neurological signs.

Thomas Welton
Francisco Cardoso
Eng-King Tan
Reviews11 Nov 2021
Nature Reviews Disease Primers

Volume: 7, P: 1-17
A table-top ultrashort light source in the extreme ultraviolet for circular dichroism experiments

A table-top source based on high-harmonic generation produces bright, coherent, quasi-circular pulses of extreme ultraviolet light for probing chiral molecules.

A. Ferré
C. Handschin
Y. Mairesse
Research22 Dec 2014
Nature Photonics

Volume: 9, P: 93-98
Excitatory neurons in paraventricular hypothalamus contributed to the mechanism underlying acupuncture regulating the swallowing function

Si Yuan
Bing Deng
Nenggui Xu
ResearchOpen Access06 Apr 2022
Scientific Reports

Volume: 12, P: 1-11
Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors

U. Maskos
B. E. Molles
J.-P. Changeux
Research07 Jul 2005
Nature

Volume: 436, P: 103-107
Prediction of the intestinal resistome by a three-dimensional structure-based method

Development of a structure-based method to predict potential ARDs present in human metagenomes indicates that resistance genes are rarely transferred within the human gut, and that individuals can be clustered into resistotypes.

Etienne Ruppé
Amine Ghozlane
S. Dusko Ehrlich
Research26 Nov 2018
Nature Microbiology

Volume: 4, P: 112-123
Transancestral mapping and genetic load in systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong ethnic and gender bias. In a transancestral genetic association study, Langefeldet al. identify 24 novel regions associated with risk to lupus and propose a cumulative hits hypothesis for loci conferring risk to SLE.

Carl D. Langefeld
Hannah C. Ainsworth
Timothy J. Vyse
ResearchOpen Access17 Jul 2017
Nature Communications

Volume: 8, P: 1-18
LRRK2-mutant microglia and neuromelanin synergize to drive dopaminergic neurodegeneration in an iPSC-based Parkinson’s disease model

iPSC-based disease modeling demonstrates that neuromelanin and LRRK2 mutations cooperate to promote microglia-mediated dopaminergic neurodegeneration in Parkinson’s disease.

Lucas Blasco-Agell
Meritxell Pons-Espinal
Antonella Consiglio
ResearchOpen Access12 Aug 2025
Communications Biology

Volume: 8, P: 1-15
Clinical, neuropathological, and genetic characterization of STUB1 variants in cerebellar ataxias: a frequent cause of predominant cognitive impairment

Thomas Roux
Mathieu Barbier
Nicholas Wood
Research27 Jul 2020
Genetics in Medicine

Volume: 22, P: 1851-1862
Prognostic neuroimaging biomarkers of trauma-related psychopathology: resting-state fMRI shortly after trauma predicts future PTSD and depression symptoms in the AURORA study

Nathaniel G. Harnett
Sanne J. H. van Rooij
Jennifer S. Stevens
Research21 Jan 2021
Neuropsychopharmacology

Volume: 46, P: 1263-1271
The innate immune toll-like-receptor-2 modulates the depressogenic and anorexiolytic neuroinflammatory response in obstructive sleep apnoea

Dora Polsek
Diana Cash
Ivana Rosenzweig
ResearchOpen Access10 Jul 2020
Scientific Reports

Volume: 10, P: 1-13
Impact of early nutrition on brain development and neurocognitive outcomes in very preterm infants

Nima Naseh
Tânia F. Vaz
Johan Ågren
ResearchOpen Access04 Mar 2025
Pediatric Research

Volume: 98, P: 593-598
Alterations of the human gut microbiome in liver cirrhosis

Invasion of the gut by oral bacteria in liver cirrhosis.

Nan Qin
Fengling Yang
Lanjuan Li
Research23 Jul 2014
Nature

Volume: 513, P: 59-64
Corpus callosum morphology and relationships to illness phenotypes in individuals with anorexia nervosa

Jamie D. Feusner
Alicja Nowacka
Florian Kurth
ResearchOpen Access15 May 2024
Scientific Reports

Volume: 14, P: 1-10
Brain metabolic imaging-based model identifies cognitive stability in prodromal Alzheimer’s disease

Jarrad Perron
Carly Scramstad
Ji Hyun Ko
ResearchOpen Access17 May 2025
Scientific Reports

Volume: 15, P: 1-14
Lack of Sex Differences in Antioxidant Enzyme Development in the Fetal Rabbit Lung

Ilene R S Sosenko
Heber C Nielsen
Lee Frank
Research01 Jul 1989
Pediatric Research

Volume: 26, P: 16-19
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

Here 106 genomic loci associated with age at menarche, a marker of puberty timing in females, are identified; these loci show enrichment for genes involved in nuclear hormone receptor function, body mass index, and rare disorders of puberty, and for genes located in imprinted regions, with parent-of-origin specific effects at several loci.

John R. B. Perry
Felix Day
Ken K. Ong
Research23 Jul 2014
Nature

Volume: 514, P: 92-97
Defining the cell of origin for diffuse midline gliomas

K27M mutation of histone H3 has been identified as a driver event in diffuse midline glioma. Two studies used comprehensive multi-model single-cell genomic, epigenomic and chromatin structure analysis to characterize the cell of origin and find a distinct etiology of H3K27M between pontine and thalamic tumors, and show that pontine gliomas harbor more immature oligodendrocyte-precursor-like cells.

Xiao-Nan Li
News & Views05 Dec 2022
Nature Genetics

Volume: 54, P: 1770-1771

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