Ash2L is part of a complex involved in histone H3 lysine 4 trimethylation, linked to active transcription. Ash2L is now found to contain a helix-wing-helix DNA binding domain that is needed for targeting and H3K4 trimethylation at the β-globin locus control region in vivo.
- Sabina Sarvan
- Vanja Avdic
- Jean-François Couture
