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Advanced filters: Author: Sabine Druillennec Clear advanced filters

RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma

The melanoma-driver mutations in NRAS and BRAF are mutually exclusive but the contribution of RAF signalling downstream of NRAS remains to be clarified. Here, using mouse models, the authors show specific roles of each member of the RAF family at different stages of melanomagenesis.

Coralie Dorard
Charlène Estrada
Sabine Druillennec
ResearchOpen Access12 May 2017
Nature Communications

Volume: 8, P: 1-13
Translational control of tumor immune escape via the eIF4F–STAT1–PD-L1 axis in melanoma

The translation initiation complex mediates tumor immune escape in melanoma by controlling STAT1 mRNA levels and T lymphocyte–induced PD-L1 expression.

Michaël Cerezo
Ramdane Guemiri
Caroline Robert
Research29 Oct 2018
Nature Medicine

Volume: 24, P: 1877-1886
MITF activity is regulated by a direct interaction with RAF proteins in melanoma cells

The MITF transcription factor directly binds to the kinase domain of RAF kinases, including ARAF, BRAF and CRAF in melanoma cells. RAF/MITF complex promotes cytoplasmic accumulation of MITF and thus negatively regulates its transcriptional activity.

Charlène Estrada
Liliana Mirabal-Ortega
Sabine Druillennec
ResearchOpen Access28 Jan 2022
Communications Biology

Volume: 5, P: 1-13

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