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Showing 1–3 of 3 results
Advanced filters: Author: Sabine Harlander Clear advanced filters

  • Genetic inactivation of VHL leads to stabilization of HIF-1α/HIF-2α and is associated with clear cell renal cell carcinoma (ccRCC) initiation and progression. Using an autochthonous mouse model of ccRCC with Vhl deletion, here the authors show that HIF-1α is necessary for tumor formation, while HIF-2α deletion has only a moderate effect.

    • Rouven Hoefflin
    • Sabine Harlander
    • Ian J. Frew
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-21

  • Renal angiomyolipomas (AML) contain a mix of clonal tumour cells. Here, through reverse tumour engineering experiments, mouse genetics and analyses of human AML tumours, the authors provide evidence that these mesenchymal tumours originate from renal proximal tubule epithelial cells.

    • Ana Filipa Gonçalves
    • Mojca Adlesic
    • Ian J. Frew
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • Through combined deletion of Vhl, Trp53 and Rb1 in renal epithelial cells, the authors develop a new mouse model of renal cell carcinoma that recapitulates the cellular and molecular features of a large proportion of human tumors. This model uncovers a role for primary-cilium-related genes in the development of the disease and provides a reliable platform for preclinical therapeutic studies.

    • Sabine Harlander
    • Désirée Schönenberger
    • Ian J Frew
    Research
    Nature Medicine
    Volume: 23, P: 869-877