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Showing 1–3 of 3 results
Advanced filters: Author: Sabine Studer Clear advanced filters

  • A de novo designed zinc-binding protein has been converted into a highly active, stereoselective catalyst for a hetero-Diels–Alder reaction. Design and directed evolution were used to effectively harness Lewis acid catalysis and create an enzyme more proficient than other reported Diels–Alderases.

    • Sophie Basler
    • Sabine Studer
    • Donald Hilvert
    Research
    Nature Chemistry
    Volume: 13, P: 231-235

  • Neurons and oligodendrocytes differentiated from induced pluripotent stem cells (iPSCs) of patients with inherited TLR3 and UNC-93B deficiencies are found to be more susceptible to infection by HSV-1 than control cells because they fail to induce a normal interferon response, whereas neural stem cells and astrocytes are not susceptible.

    • Fabien G. Lafaille
    • Itai M. Pessach
    • Luigi D. Notarangelo
    Research
    Nature
    Volume: 491, P: 769-773