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Showing 1–4 of 4 results
Advanced filters: Author: Sabrina Lindinger Clear advanced filters

  • Maintenance of a mitochondrial NAD+ pool is critical for cellular life, yet the existence and identity of the transporter responsible for mitochondrial NAD+ uptake was unknown until recently. Here, the authors use genomic, genetic, and metabolomic approaches to demonstrate that SLC25A51 controls NAD+ mitochondrial levels and is the functional homolog of the yeast mitochondrial NAD+ transporter.

    • Enrico Girardi
    • Gennaro Agrimi
    • Giulio Superti-Furga
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • A set of CRISPR–Cas9-based genetic screens in a haploid human cell line identifies more than 200 gene–drug associations involving solute carriers (SLCs), transporters important for the uptake and activity of cytotoxic drugs.

    • Enrico Girardi
    • Adrián César-Razquin
    • Giulio Superti-Furga
    Research
    Nature Chemical Biology
    Volume: 16, P: 469-478

  • The Innovative Medicines Initiative Consortium RESOLUTE has started to develop tools and produce data sets to de-orphanize transporters in the solute carrier protein (SLC) superfamily, thereby lowering the barrier for the scientific community to explore SLCs as an attractive drug target class.

    • Giulio Superti-Furga
    • Daniel Lackner
    • Claire M. Steppan
    Comments & Opinion
    Nature Reviews Drug Discovery
    Volume: 19, P: 429-430