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Showing 1–4 of 4 results
Advanced filters: Author: Sacha Krieg Clear advanced filters

  • Researchers induced ploidy reduction in human oocytes generated by somatic cell nuclear transfer, enabling fertilization and embryo development with integrated somatic and sperm chromosomes, highlighting a proof-of-concept for in vitro gametogenesis.

    • Nuria Marti Gutierrez
    • Aleksei Mikhalchenko
    • Shoukhrat Mitalipov
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • DNA repair in response to DSBs in the preimplantation embryo is hard to analyze. Here the authors show that over 25% of pre-existing heterozygous loci in control single blastomere samples appeared as homozygous after whole genome amplification, therefore, they validated gene editing seen in human embryos in ESCs.

    • Dan Liang
    • Aleksei Mikhalchenko
    • Shoukhrat Mitalipov
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.

    • Hong Ma
    • Nuria Marti-Gutierrez
    • Shoukhrat Mitalipov
    Research
    Nature
    Volume: 548, P: 413-419

    • Hong Ma
    • Nuria Marti-Gutierrez
    • Shoukhrat Mitalipov
    Research
    Nature
    Volume: 560, P: E10-E23