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Showing 1–4 of 4 results
Advanced filters: Author: Sachith D. Gunasinghe Clear advanced filters

  • T cells can recognise lipid antigen in the context of CD1d molecules. Here, the authors show that γδ T cell activation in response to CD1d differs from that of αβ T cells and determine the structure of a γδ T cell receptor that binds to CD1d independently of the presented lipid.

    • Michael T. Rice
    • Sachith D. Gunasinghe
    • Jamie Rossjohn
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-12

  • Cryogenic electron microscopy determines the structure of a fully assembled, MR1-reactive, human Vγ8Vδ3 TCR–CD3δγε2ζ2 complex bound by anti-CD3ε antibody Fab fragments.

    • Benjamin S. Gully
    • João Ferreira Fernandes
    • Simon J. Davis
    ResearchOpen Access
    Nature
    Volume: 634, P: 729-736

  • Certain specific antigens have been shown to activate T cells in an MHC independent manner. Here the authors show a phycoerythrin reactive mouse TCR which recognises native protein and characterise the molecular nature of this interaction and that this specific TCR can be selected in the thymus.

    • Catarina F. Almeida
    • Benjamin S. Gully
    • Dale I. Godfrey
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • T cell receptors are generally thought to contact antigens presented in an end to end configuration. Here the authors show a geometrically alternate sideways mode of recognition of the antigen-presenting molecule CD1a by a γδ T cell receptor.

    • Marcin Wegrecki
    • Tonatiuh A. Ocampo
    • Jamie Rossjohn
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15