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Showing 1–7 of 7 results
Advanced filters: Author: Sadhana Gaddam Clear advanced filters

  • Thomas, Noishiki, Gaddam et al. used thrombotic vascular tissues and iPSC-derived cardiac organoids to show that COVID-19-induced endotheliitis and cytokine release disrupt endothelial–cardiomyocyte crosstalk and contribute to cardiac dysfunction in long COVID.

    • Dilip Thomas
    • Chikage Noishiki
    • Nazish Sayed
    Research
    Nature Cardiovascular Research
    Volume: 3, P: 1249-1265

  • Cancer-associated inflammation dynamics need further characterization. Here, the authors identify an inflammation and therapy-enriched tumor state termed basal- to-inflammatory transition associated with poor survival in many epithelial tumors and suggest its therapeutic targeting.

    • Nancy Yanzhe Li
    • Weiruo Zhang
    • Anthony E. Oro
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • The identification of distinct cell populations with cellular plasticity in skin basal cell carcinoma is important for understanding treatment resistance mechanisms. Here, the authors identify the resistant LY6D+ basosquamous population that correlates with poor clinical outcomes.

    • Daniel Haensel
    • Sadhana Gaddam
    • Anthony E. Oro
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Tumor microenvironment elements can influence tumor state, including in skin basal cell carcinomas. Here the authors show that spatially organized and self-propagating TREM2+ tumor associated macrophages promote Ly6D- tumor cell proliferation via secretion of oncostatin M.

    • Daniel Haensel
    • Bence Daniel
    • Anthony E. Oro
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-22

  • Characterization of Gibbin, encoded by AHDC1, offers insights into the epidermal and mesodermal patterning phenotypes seen in Xia–Gibbs and related syndromes in humans, which derive from abnormal mesoderm maturation as a result of gene-specific DNA methylation decisions.

    • Ann Collier
    • Angela Liu
    • Anthony E. Oro
    Research
    Nature
    Volume: 606, P: 188-196

  • Basal cell carcinoma (BCC) cells with increased nuclear myocardin-related transcription factor (nMRTF) levels are resistant to Smoothened inhibitors, however how MRTF activity is regulated is still elusive. Here, the authors identify a LYPD3+/TACSTD2+/LY6D+ BCC subpopulation of resistant BCC cells where AP-1 and TGFß drive nMRTF activation and amplify noncanonical Gli1 activity

    • Catherine D. Yao
    • Daniel Haensel
    • Anthony E. Oro
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17