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Showing 1–3 of 3 results
Advanced filters: Author: Safa Beydoun Clear advanced filters

  • Beydoun, Choi et al. develop a metabolically inactive food source for C. elegans worms that minimizes the confounding effects of bacterial metabolism on worm metabolism and aging. They find that worms eat and grow well on a paraformaldehyde (PFA)-treated E. coli food source, recommending the use of 0.5% PFA-killed bacteria as a nematode food source for metabolic experiments.

    • Safa Beydoun
    • Hyo Sub Choi
    • Scott F. Leiser
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-9

  • Flavin containing monooxygenase 2 (FMO-2) is known to increase lifespan under dietary restriction through incompletely understood mechanisms. Here the authors report that FMO-2 modifies tryptophan and methionine metabolic pathways to enhance stress resistance and slow aging in C. elegans.

    • Hyo Sub Choi
    • Ajay Bhat
    • Scott F. Leiser
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • This report finds that dietary restriction, the most extensively studied anti-aging intervention, can be mimicked by blocking food odour signaling and identifies a neural network of food perception that functions through serotonin and dopamine.

    • Hillary A. Miller
    • Shijiao Huang
    • Scott F. Leiser
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13