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Showing 1–5 of 5 results
Advanced filters: Author: Sagar P. Bapat Clear advanced filters

  • Obesity changes the characteristics of the immune response induced in a mouse model of atopic dermatitis, suggesting therapies that could be used against immune dysregulation in obesity.

    • Sagar P. Bapat
    • Caroline Whitty
    • Alexander Marson
    Research
    Nature
    Volume: 604, P: 337-342

  • Highly accurate antibody tests for SARS-CoV-2 are needed for surveillance in low-prevalence populations. Here, the authors find seroprevalence of less than 1% in two San Francisco Bay Area populations at the beginning of April, and that seroreactivity is generally predictive of in vitro neutralising activity.

    • Dianna L. Ng
    • Gregory M. Goldgof
    • Charles Y. Chiu
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-7

  • Genome-wide CRISPR screens, biochemical studies and animal models show that RASA2 has a key role in regulating T cell function and has potential as a genetic target for enhancing anti-tumour immunity.

    • Julia Carnevale
    • Eric Shifrut
    • Alexander Marson
    ResearchOpen Access
    Nature
    Volume: 609, P: 174-182

  • Fat-resident regulatory T cells (fTreg cells) accumulate in adipose tissue of mice as a function of age, but not obesity; mice without fTreg cells are protected against age-associated insulin resistance, but remain susceptible to obesity-associated insulin resistance and metabolic disease, indicating different aetiologies of age-associated versus obesity-associated insulin resistance.

    • Sagar P. Bapat
    • Jae Myoung Suh
    • Ye Zheng
    Research
    Nature
    Volume: 528, P: 137-141