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Showing 1–4 of 4 results
Advanced filters: Author: Saheem A. Zaidi Clear advanced filters

  • δ-Opioid receptors (δOR) are promising targets for pain management with reduced side effects. Here, the authors use a structure-based approach to design and characterize C6-Quino, a selective δOR partial agonist, highlighting its potential therapeutic relevance.

    • Balazs R. Varga
    • Sarah M. Bernhard
    • Tao Che
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Bitopic functionalized ligands based on fentanyl can target the sodium ion-binding site of the mu-opioid receptor and selectively modulate downstream signalling pathways, potentially leading to safer analgesics.

    • Abdelfattah Faouzi
    • Haoqing Wang
    • Susruta Majumdar
    Research
    Nature
    Volume: 613, P: 767-774

  • Ibogaine is a natural substance that interrupts opioid addiction but has cardiac risks. This article introduces novel ibogaine analogs that show reduced cardiac risk and enhanced neuroplasticity and therapeutic-like effects in models of opioid use disorder.

    • Václav Havel
    • Andrew C. Kruegel
    • Dalibor Sames
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21