Myeloid cell subsets are playing important roles in antitumour immunity, and genes affecting their functions are potential targets for immunotherapy. Here authors show that genomic deletion of Pikfyve in CD11c+ cells results in tumour growth inhibition via enhanced antigen presentation and priming of antigen-specific CD8+ T cells in a mouse tumor model.
- Jae Eun Choi
- Yuanyuan Qiao
- Arul M. Chinnaiyan
