Microreactors are valued for efficient mixing and precise control in nanoparticle synthesis; however, when encapsulating sensitive proteins and enzymes, conventional fluidic shear causes serious damage and activity loss. Here, the authors show that gas-liquid slug-flow microchannels provide efficient mixing, narrow residence time distribution, and suitable shear compared to single-phase flow microchannels, microstructured continuous stirred-tank reactors, and batch reactors, reporting a low PDI and productivity equivalent to 100 lab-scale batch reactors for the preparation of catalase nanocapsules.
- Zhangyi Gao
- Yi Zhang
- Yuanhai Su
