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Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Marcus J. G. W. Ladds
Ingeborg M. M. van Leeuwen
Sonia Laín
Amendments and CorrectionsOpen Access18 Aug 2023
Nature Communications

Volume: 14, P: 1-3
Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Marcus J. G. W. Ladds
Ingeborg M. M. van Leeuwen
Sonia Laín
Amendments and CorrectionsOpen Access22 May 2018
Nature Communications

Volume: 9, P: 1-2
Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses

The cytokine IL-18 can drive autoantibody production. Karlsson and colleagues show that such responses are limited by a three-way cellular interaction whereby splenic neutrophils activate both B cells and invariant natural killer T cells but the activated B cells are killed by FasL⁺ invariant natural killer T cells.

Thomas Hägglöf
Saikiran K Sedimbi
Mikael C I Karlsson
Research31 Oct 2016
Nature Immunology

Volume: 17, P: 1407-1414
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Activation of the tumor suppressor p53 is a promising approach in cancer therapy. Here, the authors discover a series of small molecule dihydroorotate dehydrogenase (DHODH) inhibitors that increase p53 synthesis and reduce tumor growth in synergy with the common mdm2 inhibitor nutlin3.

Marcus J. G. W. Ladds
Ingeborg M. M. van Leeuwen
Sonia Laín
ResearchOpen Access16 Mar 2018
Nature Communications

Volume: 9, P: 1-14
MDM2 inhibitors, nutlin-3a and navtemadelin, retain efficacy in human and mouse cancer cells cultured in hypoxia

Ada Lerma Clavero
Paula Lafqvist Boqvist
Pavitra Kannan
ResearchOpen Access20 Mar 2023
Scientific Reports

Volume: 13, P: 1-12

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Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

MDM2 inhibitors, nutlin-3a and navtemadelin, retain efficacy in human and mouse cancer cells cultured in hypoxia

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