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Showing 1–8 of 8 results

Advanced filters: Author: Sakari Jukarainen Clear advanced filters

Genetic risk factors have a substantial impact on healthy life years

A new analysis combining data from large biobanks and the Global Burden of Disease study estimates that genetic risk factors significantly impact the number of healthy life years lost both at the individual and population level

Sakari Jukarainen
Tuomo Kiiskinen
Andrea Ganna
ResearchOpen Access12 Sept 2022
Nature Medicine

Volume: 28, P: 1893-1901
Socio-demographic and genetic risk factors for drug adherence and persistence across 5 common medication classes

This study examines socio-demographic and genetic factors for adherence and persistence to five medication classes, identifying lower socio-economic and immigration status as major predictors of lower adherence, while genetic factors show minimal impact.

Mattia Cordioli
Andrea Corbetta
Andrea Ganna
ResearchOpen Access23 Oct 2024
Nature Communications

Volume: 15, P: 1-13
Evidence from Finland and Sweden on the relationship between early-life diseases and lifetime childlessness in men and women

The authors present a comprehensive analysis of the associations between childlessness and individual diseases in Finland and Sweden.

Aoxing Liu
Evelina T. Akimova
Andrea Ganna
ResearchOpen Access18 Dec 2023
Nature Human Behaviour

Volume: 8, P: 276-287
Quantifying the causal impact of biological risk factors on healthcare costs

Understanding the causal impact that risk factors have on healthcare cost is critical to evaluate healthcare interventions. Here, authors show that waist circumference, body mass index, and blood pressure have robust causal impact on healthcare cost.

Jiwoo Lee
Sakari Jukarainen
Andrea Ganna
ResearchOpen Access13 Sept 2023
Nature Communications

Volume: 14, P: 1-11
High incidence and geographic distribution of cleft palate in Finland are associated with the IRF6 gene

Here, the authors perform a genome-wide study and identify a genetic variant enriched in the Finnish population that is strongly associated with isolated cleft palate. This finding suggests a genetic basis for the high prevalence of cleft palate in Finland.

Fedik Rahimov
Pekka Nieminen
David P. Rice
ResearchOpen Access06 Nov 2024
Nature Communications

Volume: 15, P: 1-14
Genetic predictors of lifelong medication-use patterns in cardiometabolic diseases

A new analysis of large biobanks uncovers genetic variants associated with longitudinal changes in medication for cardiometabolic diseases and presents polygenic scores of medication-use behavior.

Tuomo Kiiskinen
Pyry Helkkula
Samuli Ripatti
ResearchOpen Access18 Jan 2023
Nature Medicine

Volume: 29, P: 209-218
Deep learning-based prediction of one-year mortality in Finland is an accurate but unfair aging marker

Here the authors show that deep learning accurately predicts one-year mortality using nationwide Finnish data. Despite robust performance and potential as an aging marker, fairness analyses reveal prediction disparities, urging cautious integration into public health.

Andrius Vabalas
Tuomo Hartonen
Andrea Ganna
ResearchOpen Access24 Jun 2024
Nature Aging

Volume: 4, P: 1014-1027
Cost minimization analysis of digital-first healthcare pathways in primary care

Alexandra Dahlberg
Sakari Jukarainen
Petja Orre
ResearchOpen Access25 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-9