Transcription factor STAT3 constitutively activated in cancer promotes tumor progression. The authors detected activated STAT3 in human metastatic melanoma cells and identified new STAT3 targets. STAT3 regulates a discrete set of genes in melanoma cells and its knockdown impairs cell migration and invasion via regulation of its transcriptional target SERPINA3.
- Dorota W. Kulesza
- Kavita Ramji
- Bozena Kaminska