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IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses

IgSF9b is a synaptic adhesion protein that has been linked to psychiatric disorders. Here the authors show that deletion of IgSF9b regulates anxiety-like behaviour in mice by increasing inhibitory synaptic transmission in the centromedial amygdala.

Olga Babaev
Hugo Cruces-Solis
Dilja Krueger-Burg
ResearchOpen Access20 Dec 2018
Nature Communications

Volume: 9, P: 1-16
Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABA_ARs and cytosolic gephyrin aggregation

Analysis of inhibitory synapses in mouse hippocampus uncovers functional interactions between postsynaptic organizer proteins Neuroligin-2 and MDGA1 in regulating gephyrin aggregation, GABAergic synaptic transmission, and behavior.

Tommaso Zeppillo
Heba Ali
Dilja Krueger-Burg
ResearchOpen Access17 Sept 2024
Communications Biology

Volume: 7, P: 1-15

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IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses

Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABAARs and cytosolic gephyrin aggregation

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Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABA_ARs and cytosolic gephyrin aggregation