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Showing 1–7 of 7 results

Advanced filters: Author: Salman R Khetani Clear advanced filters

Liver portal fibroblasts induce the functions of primary human hepatocytes in vitro

Human liver portal fibroblasts can enhance and stabilize the functions of primary human hepatocytes in both 2-dimensional and 3-dimensional culture formats, and such occurs partly due to insulin-like growth factor binding protein 5 signaling.

Grace E. Brown
Vedant V. Bodke
Salman R. Khetani
ResearchOpen Access09 May 2025
Communications Biology

Volume: 8, P: 1-17
Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens

This protocol uses micropatterned co-cultures comprising 2D islands of primary human hepatocytes surrounded by supportive fibroblast cells to model liver infection by the hepatitis B and C viruses or Plasmodium pathogens in vitro.

Sandra March
Vyas Ramanan
Sangeeta N Bhatia
Protocols19 Nov 2015
Nature Protocols

Volume: 10, P: 2027-2053
Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system

Hepatitis C virus research is hampered by the inability to detect individual infected cells. Jones et al. achieve this by imaging the translocation of a fluorescent reporter protein after cleavage by a viral protease in living or fixed cells.

Christopher T Jones
Maria Teresa Catanese
Charles M Rice
Research31 Jan 2010
Nature Biotechnology

Volume: 28, P: 167-171
Microscale culture of human liver cells for drug development

Salman R Khetani
Sangeeta N Bhatia
Research18 Nov 2007
Nature Biotechnology

Volume: 26, P: 120-126
LIGHT enhanced bispecific antibody armed T-cells to treat immunotherapy resistant colon cancer

Guilin Qiao
Lyonell B. Kone
Ajay V. Maker
ResearchOpen Access17 Feb 2022
Oncogene

Volume: 41, P: 2054-2068
A human iPSC-derived hepatocyte screen identifies compounds that inhibit production of Apolipoprotein B

iPSC-derived hepatocytes are used to identify small molecule inhibitors of apoB secretion by the liver without causing steatosis.

Jui-Tung Liu
Caren Doueiry
Stephen A. Duncan
ResearchOpen Access24 Apr 2023
Communications Biology

Volume: 6, P: 1-17
Long-term exposure to abnormal glucose levels alters drug metabolism pathways and insulin sensitivity in primary human hepatocytes

Matthew D. Davidson
Kimberly R. Ballinger
Salman R. Khetani
ResearchOpen Access17 Jun 2016
Scientific Reports

Volume: 6, P: 1-11