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Showing 1–7 of 7 results
Advanced filters: Author: Sam Astbury Clear advanced filters

  • In this work, using a combination of Cryo-EM, in-cell experiments and biophysical analysis, the authors decoded the aggregation propensity of tau, revealing 5 central hot spots in its primary sequence and identify PAM4 as short segment that determines both the structure, as well as the cellular propagation of tau aggregates extracted from Alzheimer’s disease, corticobasal degeneration, and progressive supranuclear palsy patients.

    • Nikolaos Louros
    • Martin Wilkinson
    • Joost Schymkowitz
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • CDC25 phosphatases are attractive anticancer drug targets that regulate CDK activity. Here, the authors present the cryo-EM structure of the CDK2-cyclin A-CDC25A complex at 2.7 Å resolution, detailing key protein-protein interactions.

    • Rhianna J. Rowland
    • Svitlana Korolchuk
    • Jane A. Endicott
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Patel et al. investigate the role of RNA sequence/structure motif ‘Packaging Signals’ (PSs) in regulating the assembly of an HBV genome transcript using an in vitro assay containing only core protein (Cp) and RNA. They show that RNA PSs regulate assembly of HBV genomic transcripts in vitro, and therefore may play similar roles in vivo, in concert with other molecular factors.

    • Nikesh Patel
    • Sam Clark
    • Peter G. Stockley
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-12

  • Laser-driven X-rays can provide ultrashort pulses of broadband light, well suited for femtosecond timescale absorption spectroscopy. Here the authors measure the extended X-ray absorption features of a copper sample using a laser wakefield accelerator, in a single shot; important for studying samples driven to extreme and non-equilibrium states.

    • Brendan Kettle
    • Cary Colgan
    • Stuart P. D. Mangles
    ResearchOpen Access
    Communications Physics
    Volume: 7, P: 1-7

  • Lin Wang et al. present a new super-resolution modality using a super-hemispherical immersion lens. They achieve a 12 nm spatial resolution in cells under cryogenic conditions, which offers the technical means to study bacterial and mammalian cell samples at molecule localisation length-scales.

    • Lin Wang
    • Benji Bateman
    • Marisa L. Martin-Fernandez
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-11