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Showing 1–3 of 3 results
Advanced filters: Author: Sam P. B. van Beljouw Clear advanced filters

  • Single-particle tracking PALM (sptPALM) provides quantitative information in vivo if the protein of interest remains in a single diffusional state during track acquisition. Here the authors develop a custom-built sptPALM microscope and a Monte-Carlo based diffusion distribution analysis to study dynamic DNA-dCas9 interactions in live bacteria.

    • Koen J. A. Martens
    • Sam P. B. van Beljouw
    • Johannes Hohlbein
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • InstaNovo, a transformer-based model, and InstaNovo+, a multinomial diffusion model, enhance de novo peptide sequencing, enabling discovery of novel peptides, improved therapeutics sequencing coverage and detection of unreported organisms in proteomics studies

    • Kevin Eloff
    • Konstantinos Kalogeropoulos
    • Timothy P. Jenkins
    ResearchOpen Access
    Nature Machine Intelligence
    Volume: 7, P: 565-579

  • In this Review, Brouns and colleagues discuss our current understanding of RNA-targeting type III and type VI CRISPR–Cas systems by detailing their composition, properties and defence processes, and describing the biological rationale behind the broad activated immune responses as an effective strategy to combat viral infection.

    • Sam P. B. van Beljouw
    • Jasper Sanders
    • Stan J. J. Brouns
    Reviews
    Nature Reviews Microbiology
    Volume: 21, P: 21-34