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Showing 1–3 of 3 results

Advanced filters: Author: Samantha M. Sarrett Clear advanced filters

Inverse electron demand Diels–Alder click chemistry for pretargeted PET imaging and radioimmunotherapy

This approach leverages the rapid, bio-orthogonal inverse electron demand Diels–Alder reaction between a radiolabeled tetrazine and a trans-cyclooctene–bearing antibody to enable pretargeted positron emission tomography imaging and endoradiotherapy in a murine model of cancer.

Samantha M. Sarrett
Outi Keinänen
Brian M. Zeglis
Protocols14 Jun 2021
Nature Protocols

Volume: 16, P: 3348-3381
Click chemistry: a transformative technology in nuclear medicine

This Perspective explains how click chemistry—specifically, the copper-catalyzed azide–alkyne cycloaddition, the strain-promoted azide–alkyne cycloaddition and the inverse electron-demand Diels–Alder reaction—has revolutionized radiopharmaceutical chemistry.

David Bauer
Samantha M. Sarrett
Brian M. Zeglis
Reviews26 Apr 2023
Nature Protocols

Volume: 18, P: 1659-1668
Harnessing PET to track micro- and nanoplastics in vivo

Outi Keinänen
Eric J. Dayts
Brian M. Zeglis
ResearchOpen Access01 Jun 2021
Scientific Reports

Volume: 11, P: 1-12

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