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Advanced filters: Author: Sammy Barkal Clear advanced filters

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

CD24 interacts with the tumour-associated-macrophage receptor Siglec-10 to inhibit the macrophage-mediated clearance of cancer cells, revealing a new ‘don’t eat me’ signal as a potential target for cancer immunotherapy.

Amira A. Barkal
Rachel E. Brewer
Irving L. Weissman
Research31 Jul 2019
Nature

Volume: 572, P: 392-396
Small molecule inhibition of ATM kinase increases CRISPR-Cas9 1-bp insertion frequency

The mutational outcome of CRISPR-Cas9 editing can be both predictable and targeted. Here the authors show that ATM inhibitor KU-60019 increases 1 bp insertions at the targeted locus.

Heysol C. Bermudez-Cabrera
Sannie Culbertson
Richard I. Sherwood
ResearchOpen Access25 Aug 2021
Nature Communications

Volume: 12, P: 1-10

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CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

Small molecule inhibition of ATM kinase increases CRISPR-Cas9 1-bp insertion frequency

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