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Female-biased introductions produce higher predicted population size and genetic diversity in simulations of a small, isolated tiger (Panthera tigris) population

Eric Ash
Samuel Cushman
David W. Macdonald
ResearchOpen Access11 Jul 2023
Scientific Reports

Volume: 13, P: 1-15
GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis

The aspartate aminotransaminase GOT1 is important for maintaining redox balance. Here, the authors show that inhibition of GOT1 in pancreatic cancer cells leads to cell death via ferroptosis.

Daniel M. Kremer
Barbara S. Nelson
Costas A. Lyssiotis
ResearchOpen Access11 Aug 2021
Nature Communications

Volume: 12, P: 1-13
Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells

Halbrook et al. report two metabolic subgroups of pancreatic ductal adenocarcinoma cells defined by differential integrated stress response and asparagine production that permit symbiosis and phenformin resistance.

Christopher J. Halbrook
Galloway Thurston
Costas A. Lyssiotis
ResearchOpen Access21 Nov 2022
Nature Cancer

Volume: 3, P: 1386-1403
Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells

Using patient-derived colorectal cancer tumour enteroids, Schwartz et al. find that ectopic expression of hepcidin in the tumour epithelium establishes an axis to sequester iron to maintain the nucleotide pool and sustain proliferation.

Andrew J. Schwartz
Joshua W. Goyert
Yatrik M. Shah
Research21 Jun 2021
Nature Metabolism

Volume: 3, P: 969-982
Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment

This Review examines the tissue-specific metabolism and associated therapeutic vulnerabilities of mutant KRAS-driven tumours, providing a comparative discussion of intrinsic metabolism, co-occurring mutations and metabolic interactions in the microenvironment in colorectal, lung and pancreatic cancer.

Samuel A. Kerk
Thales Papagiannakopoulos
Costas A. Lyssiotis
Reviews09 Jul 2021
Nature Reviews Cancer

Volume: 21, P: 510-525
The human type 2 diabetes-specific visceral adipose tissue proteome and transcriptome in obesity

Nicholas J. Carruthers
Clarissa Strieder-Barboza
Robert W. O’Rourke
ResearchOpen Access30 Aug 2021
Scientific Reports

Volume: 11, P: 1-13
High-content fluorescence imaging with the metabolic flux assay reveals insights into mitochondrial properties and functions

Little, Kovalenko et al. couple the metabolic flux assay from the Seahorse bioanalyzer with high-content fluorescence imaging to study the coordinated biology of mitochondrial bioenergetics and properties. They demonstrate this integration generates a more comprehensive data set, allowing for further insight into mitochondrial function and dynamics.

Andrew Charles Little
Ilya Kovalenko
Costas Andreas Lyssiotis
ResearchOpen Access29 May 2020
Communications Biology

Volume: 3, P: 1-10

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Female-biased introductions produce higher predicted population size and genetic diversity in simulations of a small, isolated tiger (Panthera tigris) population

GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis

Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells

Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells

Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment

The human type 2 diabetes-specific visceral adipose tissue proteome and transcriptome in obesity

High-content fluorescence imaging with the metabolic flux assay reveals insights into mitochondrial properties and functions

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Female-biased introductions produce higher predicted population size and genetic diversity in simulations of a small, isolated tiger (Panthera tigris) population

GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis

Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells

Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells

Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment

The human type 2 diabetes-specific visceral adipose tissue proteome and transcriptome in obesity

High-content fluorescence imaging with the metabolic flux assay reveals insights into mitochondrial properties and functions

Search

Quick links