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Showing 1–7 of 7 results
Advanced filters: Author: Samuel G. Regalado Clear advanced filters

  • Scalable CRISPRa screening of cis-regulatory elements in non-cancer cell lines has proved challenging. Here, the authors describe a scalable, CRISPR activation screening framework to identify regulatory element-gene pairs in diverse cell types including cancer cells and neurons.

    • Florence M. Chardon
    • Troy A. McDiarmid
    • Jay Shendure
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Enhancer-driven genomic recording of transcriptional activity in multiplex (ENGRAM) is used for multiplex recording of the cell-type-specific activities of dozens to hundreds of cis-regulatory elements with high fidelity, sensitivity and reproducibility.

    • Wei Chen
    • Junhong Choi
    • Jay Shendure
    ResearchOpen Access
    Nature
    Volume: 632, P: 1073-1081

  • Mutations of ATRX are frequent in cancers that immortalize through the ALT (Alternative lengthening of telomeres) pathway. Here the authors show that ALT features are repressed in embryonic stem cells that lack ATRX but induced by continuous telomere instability triggered upon cell differentiation.

    • Timothy K. Turkalo
    • Antonio Maffia
    • Dirk Hockemeyer
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Hamazaki, Yang et al. report that an early pulse of retinoic acid robustly induces human gastruloids with a neural tube, segmented somites and more advanced cell types than conventional gastruloids.

    • Nobuhiko Hamazaki
    • Wei Yang
    • Jay Shendure
    ResearchOpen Access
    Nature Cell Biology
    Volume: 26, P: 1790-1803

  • The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

    • Jesse M. Engreitz
    • Heather A. Lawson
    • Ella K. Samer
    Reviews
    Nature
    Volume: 633, P: 47-57