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Showing 1–4 of 4 results
Advanced filters: Author: Samuel Hertig Clear advanced filters

  • Bacteria express adhesive proteins on their surface that recognize fibronectin. Using a mechanical stretch assay and steered molecular dynamics, Chabriaet al. demonstrate that the binding of a bacterial adhesin to fibronectin is mechanoregulated, suggesting that bacteria can sense tissue fibre stretching.

    • Mamta Chabria
    • Samuel Hertig
    • Viola Vogel
    ResearchOpen Access
    Nature Communications
    Volume: 1, P: 1-9

  • The extracellular matrix is under variable strain, but we lack the tools to detect differences in strain. Here the authors develop a probe based on a bacterial fibronectin-binding peptide that binds to relaxed fibronectin fibrils and detects relaxed matrix in cell culture, tissue slices and in vivo.

    • Simon Arnoldini
    • Alessandra Moscaroli
    • Viola Vogel
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • Allosteric GPCR modulators can achieve exquisite subtype selectivity, but the underlying mechanism is unclear. Using molecular dynamics simulations, the authors here identify a previously undetected dynamic pocket in muscarinic GPCRs that is critical for subtype selectivity of allosteric modulators.

    • Scott A. Hollingsworth
    • Brendan Kelly
    • Ron O. Dror
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • To achieve effective visual communication of complex data, it is important that biologists identify the needs of their audience — whether they are peers or an outreach audience. This guide to the available wealth of resources, ranging from software tools to professional illustrators, should help researchers to generate better figures and presentations tailored to the needs of any audience.

    • Graham T. Johnson
    • Samuel Hertig
    Comments & Opinion
    Nature Reviews Molecular Cell Biology
    Volume: 15, P: 690-698