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Showing 1–4 of 4 results
Advanced filters: Author: Samuel J. C. Crofts Clear advanced filters

  • DNA methylation rates correlate with maximum lifespan in mammals, but a precise relationship had not been defined. Here Crofts et al. develop a statistical framework to compare methylation rates at conserved age-related sites and find that methylation rates negatively scale with maximum lifespan in 42 mammalian species.

    • Samuel J. C. Crofts
    • Eric Latorre-Crespo
    • Tamir Chandra
    ResearchOpen Access
    Nature Aging
    Volume: 4, P: 27-32

  • Epigenetic clocks estimate biological age; however, the underlying processes are incompletely understood. Here the authors developed a model that describes methylation changes at the cellular level to provide a biologically interpretable predictor of epigenetic age. They reveal acceleration and bias components, and links with health traits.

    • Jan K. Dabrowski
    • Emma J. Yang
    • Tamir Chandra
    ResearchOpen Access
    Nature Aging
    Volume: 4, P: 1493-1507