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Showing 1–2 of 2 results
Advanced filters: Author: Samuel S. Bailin Clear advanced filters

  • Oakes et al., evaluated cellular and humoral immune responses after influenza vaccinations in adults. Vaccination elicited comparable serologic responses; however, adults 65 years old and over had reduced cellular immune responses, and single-cell RNA sequence analysis revealed that they had attenuated IFN transcriptional signatures in T-helper and myeloid cell subsets.

    • Jared M. Oakes
    • Joshua D. Simmons
    • Spyros A. Kalams
    ResearchOpen Access
    Communications Medicine
    P: 1-15

  • Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) is a rare but life-threatening severe cutaneous drug reaction mediated by CD8+ T cells. Here the authors characterise the immune response in skin samples at the site of tissue damage from patients affected with SJS/TEN and compare this to healthy skin or blister fluid and find populations of CD8+ T cell clonotypes expressing cytotoxic mediator molecules.

    • Andrew Gibson
    • Ramesh Ram
    • Elizabeth J. Phillips
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16