Nature Search

Absence of Atherosclerosis in the Cerebral Arteries of Chickens fed an Atherogenic Diet

SAMUEL G. KAHN
W. G. SILLER
Research18 Feb 1967
Nature

Volume: 213, P: 720-721
Publisher Correction: Structural basis of ligand recognition at the human MT₁ melatonin receptor

Benjamin Stauch
Linda C. Johansson
Vadim Cherezov
Amendments and Corrections03 May 2019
Nature

Volume: 569, P: E6
Structure-based design of bitopic ligands for the µ-opioid receptor

Bitopic functionalized ligands based on fentanyl can target the sodium ion-binding site of the mu-opioid receptor and selectively modulate downstream signalling pathways, potentially leading to safer analgesics.

Abdelfattah Faouzi
Haoqing Wang
Susruta Majumdar
Research30 Nov 2022
Nature

Volume: 613, P: 767-774
Structure, function and pharmacology of human itch GPCRs

Structural studies of the itch receptors MRGPRX2 and MRGPRX4 in complex with endogenous and synthetic ligands provide a basis for the development of therapeutic compounds for pain, itch and mast cell-mediated hypersensitivity.

Can Cao
Hye Jin Kang
Bryan L. Roth
Research17 Nov 2021
Nature

Volume: 600, P: 170-175
Virtual discovery of melatonin receptor ligands to modulate circadian rhythms

A computational screen of an ultra-large virtual library against the structure of the melatonin receptor found nanomolar ligands, and ultimately two selective MT₁ inverse agonists that induced phase advancement of the mouse circadian clock when given at subjective dusk.

Reed M. Stein
Hye Jin Kang
Margarita L. Dubocovich
Research10 Feb 2020
Nature

Volume: 579, P: 609-614
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome

Development of BRET sensors for nearly all major G proteins show that GPCR–G-protein coupling ranges from promiscuous to extremely specific, Switch III is a novel site for G-protein engineering, and optimal donor–acceptor positioning is non-obvious.

Reid H. J. Olsen
Jeffrey F. DiBerto
Ryan T. Strachan
Research04 May 2020
Nature Chemical Biology

Volume: 16, P: 841-849
HypoRiPPAtlas as an Atlas of hypothetical natural products for mass spectrometry database search

A gap exists between large-scale genome mining and mass spectral datasets for natural product discovery. Here the authors bridge the gap by developing HypoRiPPAtlas, an Atlas of hypothetical natural product structures, which is ready-to-use for in silico database search of tandem mass spectra.

Yi-Yuan Lee
Mustafa Guler
Hosein Mohimani
ResearchOpen Access14 Jul 2023
Nature Communications

Volume: 14, P: 1-17
Bespoke library docking for 5-HT_2A receptor agonists with antidepressant activity

New agonists of the serotonin 5-HT_2A receptor (5-HT_2AR) confer high brain permeability and antidepressant activity and—in contrast to classic 5-HT_2AR agonists—lack psychedelic activity.

Anat Levit Kaplan
Danielle N. Confair
Jonathan A. Ellman
Research28 Sept 2022
Nature

Volume: 610, P: 582-591
Structural basis of ligand recognition at the human MT₁ melatonin receptor

The MT₁ melatonin receptor differs markedly from 5-HT receptors and shows atypical ligand entry; its structure with various ligands sheds light on receptor specificity.

Benjamin Stauch
Linda C. Johansson
Vadim Cherezov
Research24 Apr 2019
Nature

Volume: 569, P: 284-288
XFEL structures of the human MT₂ melatonin receptor reveal the basis of subtype selectivity

Structural and functional studies show that the MT₂ melatonin receptor, unlike the MT₁ receptor, contains an extracellular opening for ligand entry, shedding light on receptor subtype specificity.

Linda C. Johansson
Benjamin Stauch
Vadim Cherezov
Research24 Apr 2019
Nature

Volume: 569, P: 289-292
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys

Deschloroclozapine (DCZ) is a broadly useful chemogenetic agonist for studies using nonhuman primates and mice. DCZ rapidly and reversibly activates DREADDs, and its binding can be visualized noninvasively by positron emission tomography.

Yuji Nagai
Naohisa Miyakawa
Takafumi Minamimoto
Research06 Jul 2020
Nature Neuroscience

Volume: 23, P: 1157-1167

Search

Filter By:

Search

Quick links