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Showing 1–5 of 5 results
Advanced filters: Author: San-Pin Wu Clear advanced filters

  • LKB1 is frequently mutated in lung squamous cell carcinomas. Here, the authors show that sole LKB1 depletion is sufficient to drive the development of this cancer, where downstream defective MKK7-JNK1/2 signalling activates the ∆Np63/p63 pathway to induce subsequent epithelial cells transformation and tumour progression.

    • Jian Liu
    • Tianyuan Wang
    • Francesco J. DeMayo
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • Transcription factor COUP-TFII is elevated in the hearts of non-ischaemic cardiomyopathy patients, but the nature of this correlation is unknown. Here the authors show that forced cardiac expression of COUP-TFII in mice causes dilated cardiomyopathy because of altered mitochondrial function and impaired metabolic remodelling.

    • San-Pin Wu
    • Chung-Yang Kao
    • Sophia Y. Tsai
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11

  • This paper identifies Tripartite motif-containing 28 (TRIM28) as a novel modulator of steroid hormone signaling. TRIM28 deficiency disrupts uterine cell functions and composition leading to fertility defects

    • Rong Li
    • Tianyuan Wang
    • Francesco J. DeMayo
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • The transcription factor SOX17 is important for uterine gland formation, fertility, and embryo implantation in mouse. Here the authors show that SOX17 is upstream of Indian hedgehog to regulate mouse uterine receptivity, and their analysis of uterine tissue from endometriosis patients suggests the same function in humans.

    • Xiaoqiu Wang
    • Xilong Li
    • Francesco J. DeMayo
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • A cell-autonomous role for the COUP-TFII transcription factor in prostate cancer cells is identified, in which COUP-TFII inhibits TGF-β signalling by binding to SMAD4; COUP-TFII promotes prostate tumorigenesis and metastasis in a mouse model, and is associated with more aggressive disease in human prostate cancers.

    • Jun Qin
    • San-Pin Wu
    • Sophia Y. Tsai
    Research
    Nature
    Volume: 493, P: 236-240