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Showing 1–11 of 11 results
Advanced filters: Author: Sander Herfst Clear advanced filters

  • Structurally resolving glycans remains a challenge. Here, the authors analyse influenza H3 hemagglutinin glycan evolution to show that over five decades of glycan incorporation highly impact structural stability and epitope accessibility, particularly in the head domain, providing key insights for vaccine design.

    • Rebeca de Paiva Froes Rocha
    • Ilhan Tomris
    • Andrew B. Ward
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • SARS-CoV-2 has rapidly spread globally and animal models to study transmission are needed. Here, Richard et al. show efficient transmission of SARS-CoV-2 between ferrets via direct contact and via the air, through respiratory droplets and/or aerosols.

    • Mathilde Richard
    • Adinda Kok
    • Sander Herfst
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-6

  • A high-resolution antigenic map of influenza A(H5) haemagglutinin (HA) enables the design of immunogenic and antigenically central vaccine HA antigens that elicit antibody responses broadly covering the A(H5) antigenic space.

    • Adinda Kok
    • Samuel H. Wilks
    • Mathilde Richard
    ResearchOpen Access
    Nature
    Volume: 647, P: 1005-1013

  • Some epidemiological data suggests that SARS-CoV-2 can be transmitted through the air over longer distances. Here, Kutter et al. show in the ferret model that SARS-CoV-2 and SARS-CoV can be transmitted through the air over more than a meter distance, however, data should be interpreted with care, as ferrets are likely more susceptible to coronavirus infections.

    • Jasmin S. Kutter
    • Dennis de Meulder
    • Sander Herfst
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-8

  • Here, the authors perform simultaneous inoculation of genetically tagged influenza A virus in ferrets and show that airborne transmissible viruses are preferentially transmitted from the upper respiratory tract, which correlates with high replication ability in the ferret and human nasal respiratory epithelium.

    • Mathilde Richard
    • Judith M. A. van den Brand
    • Sander Herfst
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Spillover of avian A(H5N1) influenza virus to mammals may favour adaptation to these new hosts. Air sampling of infected ferrets shows that recent A(H5N1) strains, including one from a human case linked to the US cattle outbreak, are efficiently expelled into the air.

    • Ilona I. Tosheva
    • Fabien Filaire
    • Sander Herfst
    ResearchOpen Access
    Nature Microbiology
    Volume: 10, P: 14-19

  • Here, Broszeit et al. show that circulating A/H3N2 viruses have evolved binding specificity to α2,6-sialosides on extended LacNAc moieties and therefore cannot agglutinate erythrocytes. Applying glycan remodeling allows to install functional receptors on erythrocytes and promotes identification of newly circulating variants to facilitate vaccine design.

    • Frederik Broszeit
    • Rosanne J. van Beek
    • Geert-Jan Boons
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • An investigation into the transmissibility of the H7N9 influenza A virus in ferrets finds that although the virus has some determinants associated with human adaptation and transmissibility between mammals, the airborne transmission between ferrets is limited.

    • Mathilde Richard
    • Eefje J. A. Schrauwen
    • Ron A. M. Fouchier
    Research
    Nature
    Volume: 501, P: 560-563

  • The findings of a World Health Organization expert working group that is developing animal models to test vaccines and therapeutic agents for the treatment of COVID-19, and their relevance for preclinical testing, are reviewed.

    • César Muñoz-Fontela
    • William E. Dowling
    • Dan H. Barouch
    Reviews
    Nature
    Volume: 586, P: 509-515

  • A highly pathogenic H5N1 influenza virus is spreading in U.S. dairy cattle and has been transmitted to other species, including humans, probably through contaminated milk. Understanding how the virus spreads among cattle and its potential for mammalian adaptation and airborne transmission is crucial for effective outbreak control and public health safety.

    • Fabien Filaire
    • Sander Herfst
    News & Views
    Lab Animal
    Volume: 53, P: 224-225