Polarized transport to axons and dendrites is critical for neuronal function, but the molecular mechanisms and cytoskeletal cues for asymmetry are incompletely defined. Here the authors show that Caenorhabditis elegans CRMP (UNC-33) acts early in neuronal development, together with ankyrin (UNC-44), to polarize microtubule organization and kinesin-dependent axon-dendrite sorting.
- Tapan A Maniar
- Miriam Kaplan
- Cornelia I Bargmann
