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Showing 1–5 of 5 results
Advanced filters: Author: Sandra Martin-Salamanca Clear advanced filters

  • Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and trajectories vary during health, inflammation and cancer.

    • Daniela Cerezo-Wallis
    • Andrea Rubio-Ponce
    • Iván Ballesteros
    ResearchOpen Access
    Nature
    Volume: 649, P: 1003-1012

  • High-dimensional datasets derived from time-resolved live imaging of leukocytes in mice were used to identify leukocyte identities and dynamic neutrophil states with high cellular resolution.

    • Georgiana Crainiciuc
    • Miguel Palomino-Segura
    • Andrés Hidalgo
    Research
    Nature
    Volume: 601, P: 415-421

  • Neutrophils demonstrate highly dynamic functional and transcriptional changes depending on their tissue environment. Udalova and colleagues use an inflammation model to examine neutrophils and find that the transcription factors RUNX1 and KLF6 control maturation; RELB, IRF5 and JUNB drive effector responses; and RFX2 and RELB promote survival.

    • Tariq E. Khoyratty
    • Zhichao Ai
    • Irina A. Udalova
    Research
    Nature Immunology
    Volume: 22, P: 1093-1106

  • Myeloproliferative neoplasms are caused by mutations in the haematopoietic stem cell (HSC) compartment, and here the authors show that the HSC niche contributes to the pathogenesis; sympathetic innervation of mesenchymal stem cells (MSCs) is reduced in the bone marrow of patients, which leads to reduced MSC numbers and increased mutant HSC expansion, and restoring sympathetic regulation of MSCs with neuroprotective/sympathomimetic drugs prevents mutant HSC expansion.

    • Lorena Arranz
    • Abel Sánchez-Aguilera
    • Simón Méndez-Ferrer
    Research
    Nature
    Volume: 512, P: 78-81