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Generation of pancreatic β cells from CD177⁺ anterior definitive endoderm

Markers that distinguish pancreatic and hepatic progenitors improve stem-cell differentiation to pancreatic β cells.

Pallavi U. Mahaddalkar
Katharina Scheibner
Heiko Lickert
Research27 Apr 2020
Nature Biotechnology

Volume: 38, P: 1061-1072
HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex

Using a composite bioinformatics approach, the DNA:DNA:RNA triplex-forming lncRNAs HIF1α-AS1 was identified in human endothelial cells which recruits an epigenetic silencing complex to limit expression of triplex target genes.

Matthias S. Leisegang
Jasleen Kaur Bains
Ralf P. Brandes
ResearchOpen Access02 Nov 2022
Nature Communications

Volume: 13, P: 1-20

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Generation of pancreatic β cells from CD177+ anterior definitive endoderm

HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex

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Generation of pancreatic β cells from CD177⁺ anterior definitive endoderm