Nature Search

Multivariate genetic analyses of 2.2 million individuals reveal broad and substance-specific pathways of addiction risk

In this study, the authors examine the potential shared genetic vulnerability across externalizing traits related to substance use and to substance use disorders.

Holly E. Poore
Chris Chatzinakos
Peter B. Barr
ResearchOpen Access20 Mar 2026
Nature Mental Health

P: 1-12
Publisher Correction: Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry

Sandra Sanchez-Roige
Pierre Fontanillas
Abraham A. Palmer
Amendments and Corrections08 Jan 2019
Nature Neuroscience

Volume: 22, P: 503
Mapping the genetic landscape across 14 psychiatric disorders

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Andrew D. Grotzinger
Josefin Werme
Jordan W. Smoller
ResearchOpen Access10 Dec 2025
Nature

Volume: 649, P: 406-415
Shared genetic architecture between attention-deficit/hyperactivity disorder and lifespan

Laura Vilar-Ribó
Judit Cabana-Domínguez
María Soler Artigas
ResearchOpen Access11 Mar 2023
Neuropsychopharmacology

Volume: 48, P: 981-990
Emerging phenotyping strategies will advance our understanding of psychiatric genetics

Most psychiatric genetics research has contrasted diagnosed ‘cases’ and controls. Here the authors describe alternative approaches leveraging large population-based cohorts and examining disease-related endophenotypes.

Sandra Sanchez-Roige
Abraham A. Palmer
Reviews30 Mar 2020
Nature Neuroscience

Volume: 23, P: 475-480
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Different functional variants in ADH1B (and elsewhere) in Europeans and Africans strongly affect risk for alcohol dependence. Dependence only partly genetically correlates with consumption, with strong correlations to other psychiatric disorders.

Raymond K. Walters
Renato Polimanti
Arpana Agrawal
Research26 Nov 2018
Nature Neuroscience

Volume: 21, P: 1656-1669
Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction

Richard Karlsson Linnér
Travis T. Mallard
Danielle M. Dick
Amendments and Corrections06 Dec 2024
Nature Neuroscience

Volume: 28, P: 213
Publisher Correction: Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry

Sandra Sanchez-Roige
Pierre Fontanillas
Abraham A. Palmer
Amendments and Corrections11 May 2018
Nature Neuroscience

Volume: 21, P: 1018
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction

This paper identified >500 genetic loci associated with behaviors and disorders related to self-regulation, including addiction and child behavior problems. The resulting genetic risk scores predict several behavioral, medical and social outcomes.

Richard Karlsson Linnér
Travis T. Mallard
Danielle M. Dick
Research26 Aug 2021
Nature Neuroscience

Volume: 24, P: 1367-1376
Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders

Using a sample of more than 1 million individuals, Hatoum et al. identify genomic loci associated with general and substance-specific addiction risk.

Alexander S. Hatoum
Sarah M. C. Colbert
Arpana Agrawal
Research22 Mar 2023
Nature Mental Health

Volume: 1, P: 210-223
Characterizing the co-occurrence of alcohol experimentation and suicidal thoughts and behaviors in early adolescence

Séverine Lannoy
James M. Bjork
Alexis C. Edwards
ResearchOpen Access30 Jan 2026
Translational Psychiatry

Volume: 16, P: 1-11
Genome-wide association studies of lifetime and frequency of cannabis use in 131,895 individuals

Hayley H. A. Thorpe
Pierre Fontanillas
Sandra Sanchez-Roige
Research13 Oct 2025
Molecular Psychiatry

Volume: 31, P: 1061-1073
Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals

A multi-ancestry genome-wide association study of problematic alcohol use in one million individuals identified 110 risk variants and shows that multi-ancestry polygenic scores improve risk prediction compared with single-ancestry scores

Hang Zhou
Rachel L. Kember
Joel Gelernter
ResearchOpen Access07 Dec 2023
Nature Medicine

Volume: 29, P: 3184-3192
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

A genetic study identifies hundreds of loci associated with risk tolerance and risky behaviors, finds evidence of substantial shared genetic influences across these phenotypes, and implicates genes involved in neurotransmission.

Richard Karlsson Linnér
Pietro Biroli
Jonathan P. Beauchamp
Research14 Jan 2019
Nature Genetics

Volume: 51, P: 245-257
Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction

This genome-wide association study identified 12 novel loci for opioid use disorder, a common, potentially fatal condition. Analyses implicated the CNS, with gene expression enriched in brain regions associated with addiction.

Rachel L. Kember
Rachel Vickers-Smith
Henry R. Kranzler
Research28 Sept 2022
Nature Neuroscience

Volume: 25, P: 1279-1287
Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes

In 653,790 individuals, this multi-ancestral meta-analysis of tobacco use disorder finds 461 potential risk genes and hundreds of associations with health outcomes, showcasing the utility of electronic health records for genetic research.

Sylvanus Toikumo
Mariela V. Jennings
Sandra Sanchez-Roige
Research17 Apr 2024
Nature Human Behaviour

Volume: 8, P: 1177-1193
Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits

A genetic study of problematic alcohol use in 435,563 individuals, including data from the Million Veteran Program, Psychiatric Genomics Consortium and UK Biobank, found many novel risk loci and provided new insights into trait biology.

Hang Zhou
Julia M. Sealock
Joel Gelernter
Research25 May 2020
Nature Neuroscience

Volume: 23, P: 809-818
GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability

A GWAS of lifetime cannabis use reveals new risk loci, shows that cannabis use has genetic overlap with smoking and alcohol use, and indicates that the likelihood of initiating cannabis use is causally influenced by schizophrenia.

Joëlle A. Pasman
Karin J. H. Verweij
Jacqueline M. Vink
Research27 Aug 2018
Nature Neuroscience

Volume: 21, P: 1161-1170
Author Correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability

Joëlle A. Pasman
Karin J. H. Verweij
Jacqueline M. Vink
Amendments and Corrections05 Jun 2019
Nature Neuroscience

Volume: 22, P: 1196
Psychiatric genetics in the diverse landscape of Latin American populations

Latin America and the Caribbean remain largely underrepresented in psychiatric genetics research. This Review highlights the need for more research in these populations to advance genetic insights and ensure equitable precision medicine access.

Estela M. Bruxel
Diego L. Rovaris
Janitza L. Montalvo-Ortiz
Reviews02 Apr 2025
Nature Genetics

Volume: 57, P: 1074-1088
Genome-wide association study of delay discounting identifies 11 loci and reveals transdiagnostic associations across mental and physical health

Hayley H. A. Thorpe
Renata B. Cupertino
Sandra Sanchez-Roige
ResearchOpen Access25 Nov 2025
Molecular Psychiatry

Volume: 31, P: 2081-2093
Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations

Hayley H. A. Thorpe
Pierre Fontanillas
Sandra Sanchez-Roige
Research11 Jun 2024
Neuropsychopharmacology

Volume: 49, P: 1609-1618
Medical and genetic correlates of long-term buprenorphine treatment in the electronic health records

Maria Niarchou
Sandra Sanchez-Roige
Lea K. Davis
ResearchOpen Access10 Jan 2024
Translational Psychiatry

Volume: 14, P: 1-8
CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice

Sandra Sanchez-Roige
Mariela V. Jennings
Abraham A. Palmer
ResearchOpen Access12 May 2023
Translational Psychiatry

Volume: 13, P: 1-11
Parsing genetically influenced risk pathways: genetic loci impact problematic alcohol use via externalizing and specific risk

Peter B. Barr
Travis T. Mallard
Danielle M. Dick
ResearchOpen Access30 Sept 2022
Translational Psychiatry

Volume: 12, P: 1-8
Exaggerated Waiting Impulsivity Associated with Human Binge Drinking, and High Alcohol Consumption in Mice

Sandra Sanchez-Roige
Victor Baro
Theodora Duka
Research20 Jun 2014
Neuropsychopharmacology

Volume: 39, P: 2919-2927
Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry

A genome-wide association study of delay discounting (DD) on 23,127 subjects found that genotype accounted for 12% of variance in DD; the DD genetic signature overlapped with ADHD, schizophrenia, depression, smoking, personality, cognition and weight.

Sandra Sanchez-Roige
Pierre Fontanillas
Abraham A. Palmer
Research11 Dec 2017
Nature Neuroscience

Volume: 21, P: 16-18
A single-nucleus transcriptomic atlas of medium spiny neurons in the rat nucleus accumbens

Benjamin C. Reiner
Samar N. Chehimi
Richard C. Crist
ResearchOpen Access06 Aug 2024
Scientific Reports

Volume: 14, P: 1-12
Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking

Emma C. Johnson
Isabelle Austin-Zimmerman
Arpana Agrawal
ResearchOpen Access21 Jun 2024
Neuropsychopharmacology

Volume: 49, P: 1655-1665
Cross-ancestry genomic research: time to close the gap

Elizabeth G. Atkinson
Sevim B. Bianchi
Sandra Sanchez-Roige
Reviews23 Jun 2022
Neuropsychopharmacology

Volume: 47, P: 1737-1738
Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry

Sandra Sanchez-Roige
Pierre Fontanillas
Abraham A. Palmer
ResearchOpen Access02 Nov 2021
Molecular Psychiatry

Volume: 26, P: 6209-6217
Genetic investigation of the contribution of body composition to anorexia nervosa in an electronic health record setting

Taralynn Mack
Sandra Sanchez-Roige
Lea K. Davis
ResearchOpen Access19 Nov 2022
Translational Psychiatry

Volume: 12, P: 1-7
Genetic risk for major depressive disorder and loneliness in sex-specific associations with coronary artery disease

Jessica Dennis
Julia Sealock
Lea K. Davis
ResearchOpen Access03 Dec 2019
Molecular Psychiatry

Volume: 26, P: 4254-4264
Long-term moderate treadmill exercise promotes stress-coping strategies in male and female rats

Jaume F. Lalanza
Sandra Sanchez-Roige
Rosa M. Escorihuela
ResearchOpen Access05 Nov 2015
Scientific Reports

Volume: 5, P: 1-11
Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci

Joseph D. Deak
Hang Zhou
Joel Gelernter
ResearchOpen Access25 Jul 2022
Molecular Psychiatry

Volume: 27, P: 3970-3979
Genome-Wide Association Study of Loneliness Demonstrates a Role for Common Variation

Jianjun Gao
Lea K Davis
Abraham A Palmer
Research15 Sept 2016
Neuropsychopharmacology

Volume: 42, P: 811-821
Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium

Renato Polimanti
Raymond K. Walters
Joel Gelernter
Research26 Feb 2020
Molecular Psychiatry

Volume: 25, P: 1673-1687

Search

Multivariate genetic analyses of 2.2 million individuals reveal broad and substance-specific pathways of addiction risk

Publisher Correction: Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry

Mapping the genetic landscape across 14 psychiatric disorders

Shared genetic architecture between attention-deficit/hyperactivity disorder and lifespan

Emerging phenotyping strategies will advance our understanding of psychiatric genetics

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction

Publisher Correction: Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry

Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction

Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders

Characterizing the co-occurrence of alcohol experimentation and suicidal thoughts and behaviors in early adolescence

Genome-wide association studies of lifetime and frequency of cannabis use in 131,895 individuals

Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction

Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes

Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits

GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability

Author Correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability

Psychiatric genetics in the diverse landscape of Latin American populations

Genome-wide association study of delay discounting identifies 11 loci and reveals transdiagnostic associations across mental and physical health

Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations

Medical and genetic correlates of long-term buprenorphine treatment in the electronic health records

CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice

Parsing genetically influenced risk pathways: genetic loci impact problematic alcohol use via externalizing and specific risk

Exaggerated Waiting Impulsivity Associated with Human Binge Drinking, and High Alcohol Consumption in Mice

Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry

A single-nucleus transcriptomic atlas of medium spiny neurons in the rat nucleus accumbens

Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking

Cross-ancestry genomic research: time to close the gap

Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry

Genetic investigation of the contribution of body composition to anorexia nervosa in an electronic health record setting

Genetic risk for major depressive disorder and loneliness in sex-specific associations with coronary artery disease

Long-term moderate treadmill exercise promotes stress-coping strategies in male and female rats

Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci

Genome-Wide Association Study of Loneliness Demonstrates a Role for Common Variation

Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium

Search

Quick links

Search

Filter By:

Search

Quick links