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Showing 1–5 of 5 results
Advanced filters: Author: Sandra Schilbach Clear advanced filters

  • The high-resolution structure of the mammalian pre-initiation complex in different functional states provides detailed insights into the mechanism of transcription initiation.

    • Shintaro Aibara
    • Sandra Schilbach
    • Patrick Cramer
    Research
    Nature
    Volume: 594, P: 124-128

  • Rengachari et al. provide a structural investigation of Pol II initiation at snRNA gene promoters and find that the snRNA-activating protein complex enables DNA opening and transcription initiation independent of TFIIE and TFIIH in vitro.

    • Srinivasan Rengachari
    • Sandra Schilbach
    • Patrick Cramer
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 29, P: 1159-1169

  • Cryo-EM structures of the transcription preinitiation complex in the presence of the +1 nucleosome show how the general transcription factor TFIIH can interact with the nucleosome at several positions.

    • Haibo Wang
    • Sandra Schilbach
    • Patrick Cramer
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 226-232

  • RNA polymerase II needs to be imported into the nucleus to perform transcription. Fianu et al. show that RPAP2 binds to Pol II and enters the nucleus with it, before releasing it to perform transcription and returning to the cytoplasm.

    • Isaac Fianu
    • Christian Dienemann
    • Patrick Cramer
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-7