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Showing 1–3 of 3 results
Advanced filters: Author: Sandra Torregrosa-Allen Clear advanced filters

  • The NeuSMRT platform enables neutrophil-specific CAR expression in vitro and in vivo. These CAR-neutrophils in turn offer robust antitumour effects in humanized and syngeneic mouse models of glioblastoma.

    • Yun Chang
    • Kunming Shao
    • Xiaoping Bao
    Research
    Nature Biomedical Engineering
    P: 1-18

  • Given its immunosuppressive effect in glioblastoma (GBM), targeting the TIGIT-CD155 axis presents an attractive therapeutic strategy. Here, the authors develop an adoptive natural killer (iNK) cells therapy with anti-CD155 synNotch-inducible CD73 antibody production to reverse the effect of TIGIT-CD155 signaling for the treatment of GBM.

    • Kyle B. Lupo
    • Xue Yao
    • Sandro Matosevic
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17