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Showing 1–3 of 3 results

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Semaphorin-3A regulates liver sinusoidal endothelial cell porosity and promotes hepatic steatosis

Eberhard et al. show that SEMA3A regulates liver sinusoidal endothelial cell fenestrations by signaling through NRP1 and LIMK1, revealing a pathway that connects hyperlipidemia to the development of steatotic liver disease.

Daniel Eberhard
Sydney Balkenhol
Eckhard Lammert
ResearchOpen Access14 Jun 2024
Nature Cardiovascular Research

Volume: 3, P: 734-753
Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis

Griess et al. determine the lipid signatures of pancreatic islets in type 2 diabetes models. They define a lipid environment linking the endoplasmic reticulum–Golgi transport protein Tmed2 to the proinsulin processing enzyme Pcsk1 to ensure insulin production.

Kerstin Griess
Michael Rieck
Bengt-Frederik Belgardt
ResearchOpen Access21 Dec 2022
Nature Cell Biology

Volume: 25, P: 20-29
Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase

In young women, brain insulin action enhances peripheral insulin sensitivity, but only during the follicular phase of the menstrual cycle. This effect is absent in the luteal phase, possibly due to hypothalamic insulin resistance.

Julia Hummel
Charlotte Benkendorff
Martin Heni
ResearchOpen Access21 Sept 2023
Nature Metabolism

Volume: 5, P: 1475-1482