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Showing 1–3 of 3 results
Advanced filters: Author: Sangeeta Adak Clear advanced filters

  • Polyunsaturated Fatty Acids (PUFA), such as omega-3 fatty acids, are recognized for their lipid lowering and anti-inflammatory properties. Here, the authors show that endogenous lipid synthesis controls the use of PUFA and thus determine the therapeutic benefit of omega-3 fatty acid supplementation.

    • Anna Worthmann
    • Julius Ridder
    • Christian Schlein
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Germline mutations in the DNMT3A gene can cause an overgrowth syndrome associated with behavioural and hematopoietic phenotypes. Here the authors describe a mouse model of this syndrome that recapitulates many of these features, including conserved alterations in DNA methylation in the blood cells of both species.

    • Amanda M. Smith
    • Taylor A. LaValle
    • Timothy J. Ley
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Inhibition of circulating fatty acid synthase with platensimycin reduces foam cell formation in vitro and decreases aortic atherosclerosis in ApoE-deficient mice, highlighting its potential as a therapeutic target.

    • Rodrigo Meade
    • Dina Ibrahim
    • Mohamed A. Zayed
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-13