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Showing 1–6 of 6 results
Advanced filters: Author: Sanjeeb Kumar Sahu Clear advanced filters

  • Aging is accompanied by a gradual decline of cell proliferation potential. FOXM1 is a transcription factor involved in cellular proliferation and cell cycle progression. Ribeiro et al. show that cyclic expression of a truncated form of a FOXM1 transgene in vivo can delay senescence-associated progeroid and natural aging phenotypes in mice.

    • Yasuo Ouchi
    • Sanjeeb Kumar Sahu
    • Juan Carlos Izpisua Belmonte
    News & Views
    Nature Aging
    Volume: 2, P: 373-374

  • UV-light-induced DNA damage affects RNA metabolism but the underlying signalling pathways are largely unexplored. Here, the authors show that UV light triggers p38-MK2-mediated phosphorylation of the NELF complex, promoting its release from chromatin and concurrent transcriptional elongation.

    • Marina E. Borisova
    • Andrea Voigt
    • Petra Beli
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • Although the asymmetric dimethylation of histone H3R2 acts as a repressive mark, new studies reveal that symmetrically dimethylated H3R2 (H3R2me2s) is a functional histone mark in vivo. The RBBP7 co-repressor is excluded from binding H3R2me2s in favor of the coactivator WDR5, which poises euchromatic genes for transcription activation upon cell-cycle exit and differentiation.

    • Valentina Migliori
    • Julius Müller
    • Ernesto Guccione
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 136-144

  • Epithelial-to-mesenchymal transition (EMT) regulates both processes of organism development and changes in cell state causing disease. Here, the authors show that an E3 ubiquitin ligase, FBXO32, regulates EMT via CtBP1 and the transcriptional program, and also mediates cancer metastatic burden and neurogenesis.

    • Sanjeeb Kumar Sahu
    • Neha Tiwari
    • Vijay K. Tiwari
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-18

  • The interphase centrosome protein AKNA is necessary and sufficient for the organization of centrosomal microtubules, mediates delamination in the formation of the subventricular zone and regulates exit from this zone.

    • Germán Camargo Ortega
    • Sven Falk
    • Magdalena Götz
    Research
    Nature
    Volume: 567, P: 113-117